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Literature DB >> 6250621

AUG is the only initiation codon in eukaryotes.

Abstract

An analysis of mutants of the yeast Saccharomyces cerevisiae indicates that AUG is the sole codon capable of initiating translation of iso-1-cytochrome c. This result with yeast and the sequence results of numerous eukaryotic genes indicate that AUG is the only initiation codon in eukaryotes; in contrast, results with Escherichia coli and bacteriophages indicate that both AUG and GUG are initiation codons in prokaryotes. The difference can be explained by the lack of the t6 A hypermodified nucleoside (N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]threonine) in prokaryotic initiator tRNA and its presence in eukaryotic initiator tRNA.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6250621 DOI： 10.1016/0005-2787(80)90246-4

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

11 in total

1. Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.

Authors: L J MacVinish; D R Gill; S C Hyde; K A Mofford; M J Evans; C F Higgins; W H Colledge; L Huang; F Sorgi; R Ratcliff; A W Cuthbert
Journal: J Physiol Date: 1997-03-15 Impact factor: 5.182

2. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of 3'- and 5'-deletions in vivo and in vitro.

Authors: M Aebi; R Furter; F Prantl; P Niederberger; R Hütter
Journal: Curr Genet Date: 1984-04 Impact factor: 3.886

3. Initiator tRNA may recognize more than the initiation codon in mRNA: a model for translational initiation.

Authors: M C Ganoza; P Marliere; E C Kofoid; B G Louis
Journal: Proc Natl Acad Sci U S A Date: 1985-07 Impact factor: 11.205

4. Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation.

Authors: J P Boissel; T J Kasper; S C Shah; J I Malone; H F Bunn
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205

5. Identification of a ribosome-binding site for a leader peptide encoded by Rous sarcoma virus RNA.

Authors: R B Petersen; C H Hensel; P B Hackett
Journal: J Virol Date: 1984-09 Impact factor: 5.103

6. Mutational analysis of conserved positions potentially important for initiator tRNA function in Saccharomyces cerevisiae.

Authors: U von Pawel-Rammingen; S Aström; A S Byström
Journal: Mol Cell Biol Date: 1992-04 Impact factor: 4.272

AUG is the only initiation codon in eukaryotes.

1. Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.

2. Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of 3'- and 5'-deletions in vivo and in vitro.

3. Initiator tRNA may recognize more than the initiation codon in mRNA: a model for translational initiation.

4. Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation.

5. Identification of a ribosome-binding site for a leader peptide encoded by Rous sarcoma virus RNA.

6. Mutational analysis of conserved positions potentially important for initiator tRNA function in Saccharomyces cerevisiae.

7. Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae.

8. mRNA structures influencing translation in the yeast Saccharomyces cerevisiae.

9. Structural and functional analysis of separated strands of killer double-stranded RNA of yeast.

10. Saccharomyces cerevisiae ribosomes recognize non-AUG initiation codons.