Literature DB >> 6250465

Hydrolysis of Cefotaxime by a beta-lactamase from Bacteroides fragilis.

J C Pechère, R Guay, J Dubois, R Letarte.   

Abstract

A beta-lactamase isolated from a strain of Bacteroides fragilis subsp. fragilis possessed hydrolytic activity toward cefotaxime. This antibiotic was degraded to a lower extent than was cephalothin, cephaloridine, and cefamandole, whereas cefoxitin remained unaffected by the enzyme. Kinetic parameters Vmax and Km for cefotaxime were calculated at 0.172 mumol/min and 1.1 X 10(-2) mM, respectively.

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Year:  1980        PMID： 6250465      PMCID： PMC283918          DOI： 10.1128/AAC.17.6.1001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Susceptibility to beta-lactam antibiotics and production of beta-lactamase in Bacteroides fragilis.

Authors:  B Olsson; K Dornbusch; C E Nord
Journal:  Med Microbiol Immunol       Date:  1977-10-07       Impact factor: 3.402

2.  Enzymatic and immunological characterization of a new cephalosporinase from Enterobacter aerogenes.

Authors:  R Letarte; M Devaud-Felix; J C Pechere; D Allard-Leprohon
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

3.  beta-Lactamases of subspecies of Bacteroides fragilis.

Authors:  T Leung; J D Williams
Journal:  J Antimicrob Chemother       Date:  1978-07       Impact factor: 5.790

4.  Cefotoxime (HR 756) a new cephalosporin with exceptional broad-spectrum activity in vitro.

Authors:  J M Hamilton-Miller; W Brumfitt; A V Reynolds
Journal:  J Antimicrob Chemother       Date:  1978-09       Impact factor: 5.790

5.  Formation of beta-lactamase in Bacteroides fragilis: cell-bound and extracellular activity.

Authors:  B Olsson; C E Nord; T Wadström
Journal:  Antimicrob Agents Chemother       Date:  1976-05       Impact factor: 5.191

Review 6.  Cefoxitin, a semi-synthetic cephamycin: a microbiological overview.

Authors:  J Birnbaum; E O Stapley; A K Miller; H Wallick; D Hendlin; H B Woodruff
Journal:  J Antimicrob Chemother       Date:  1978-07       Impact factor: 5.790

7.  Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.

Authors:  R Labia; J Andrillon; F Le Goffic
Journal:  FEBS Lett       Date:  1973-06-15       Impact factor: 4.124

8.  In-vitro activity of new cephalosporin (HR 756) and cefazolin.

Authors:  R Vanhoff; J P Butzler; E Yourassowsky
Journal:  Lancet       Date:  1978-07-22       Impact factor: 79.321

9.  Beta-lactamase activity in anaerobic bacteria.

Authors:  A E Weinrich; V E Del bene
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

10.  Cefoxitin resistance to beta-lactamase: a major factor for susceptibility of bacteroides fragilis to the antibiotic.

Authors:  G Darland; J Birnbaum
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191
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  8 in total

1.  Emergence of resistance during beta-lactam therapy of gram-negative infections. Bacterial mechanisms and medical responses.

Authors:  J C Pechère
Journal:  Drugs       Date:  1988       Impact factor: 9.546

2.  Activity of cefoperazone and two beta-lactamase inhibitors, sulbactam and clavulanic acid, against Bacteroides spp. correlated with beta-lactamase production.

Authors:  M A Crosby; D W Gump
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

3.  Phenotypic and molecular characterization of two novel CTX-M enzymes carried by Klebsiella pneumoniae.

Authors:  Jun Cheng; Wei Gao; Jun Yin; Zhen Sun; Ying Ye; Yu-Feng Gao; Xu Li; Jia-Bin Li
Journal:  Mol Biol Rep       Date:  2009-03-18       Impact factor: 2.316

4.  Comparative antibacterial activities of 7 alpha-methoxy cephalosporins and 7 beta-methoxyiminoacetamido cephalosporins against Bacteroides fragilis.

Authors:  T Kesado; K Watanabe; Y Asahi; M Isono; K Ueno
Journal:  Antimicrob Agents Chemother       Date:  1984-01       Impact factor: 5.191

5.  Characterization of a novel AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in China.

Authors:  Qian Wang; Jun Cheng; Yan Chen; Ying Ye; Jia-Bin Li; Xue-Jun Zhang
Journal:  Curr Microbiol       Date:  2008-09-10       Impact factor: 2.188

6.  A novel SHV-type beta-lactamase variant (SHV-89) in clinical isolates in China.

Authors:  Jia-Bin Li; Jun Cheng; Qian Wang; Yan Chen; Ying Ye; Xue-Jun Zhang
Journal:  Mol Biol Rep       Date:  2008-06-29       Impact factor: 2.316

7.  Cefotaxime therapy of serious bacterial infection in adults.

Authors:  D T Mullaney; J F John
Journal:  Antimicrob Agents Chemother       Date:  1982-03       Impact factor: 5.191

8.  Effect of clavulanic acid on the activities of ten beta-lactam agents against members of the Bacteroides fragilis group.

Authors:  F Lamothe; F Auger; J M Lacroix
Journal:  Antimicrob Agents Chemother       Date:  1984-05       Impact factor: 5.191
  8 in total

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