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Literature DB >> 6248855

Analysis of the closely linked adult chicken alpha-globin genes in recombinant DNAs.

Abstract

Recombinant bacteriophage (from a library of chicken chromosomal DNA fragments inserted into lambda Charon 4A) have been isolated which contain the coding information for both of the adult chicken alpha-globin genes, alpha A and alpha D. One of these recombinant phage also contains an as yet unidentified embryonic alpha-like globin gene sequence. The two adult genes are encoded on the same DNA strand and are separated by approximately 2.4 kilobase pairs, with the arrangement of the genes relative to the direction of transcription being 5'-alpha D-alpha A-3'. Electron microscopic R-loop visualization experiments demonstrate that both alpha-globin genes contain two intervening sequences of similar size in a manner analogous to the structure observed in the mouse alpha-globin gene. The linkage of the two highly divergent chicken adult alpha-globin genes further underscores the principle that chromosomal clustering of families of developmentally related genes may be a general phenomenon in higher eukaryotic gene sequence arrangement.

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Year: 1980 PMID： 6248855 PMCID： PMC349449 DOI： 10.1073/pnas.77.5.2596

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

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Journal: J Mol Biol Date: 1975-01-25 Impact factor: 5.469

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Journal: Proc Natl Acad Sci U S A Date: 1978-02 Impact factor: 11.205

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Authors: J L Brown; V M Ingram
Journal: J Biol Chem Date: 1974-06-25 Impact factor: 5.157

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Journal: Dev Biol Date: 1973-02 Impact factor: 3.582

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Authors: U Flamm; J S Best; G Braunitzer
Journal: Hoppe Seylers Z Physiol Chem Date: 1971-07

6. Charon phages: safer derivatives of bacteriophage lambda for DNA cloning.

Authors: F R Blattner; B G Williams; A E Blechl; K Denniston-Thompson; H E Faber; L Furlong; D J Grunwald; D O Kiefer; D D Moore; J W Schumm; E L Sheldon; O Smithies
Journal: Science Date: 1977-04-08 Impact factor: 47.728

7. Hybridization of RNA to double-stranded DNA: formation of R-loops.

Authors: M Thomas; R L White; R W Davis
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

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Authors: T Maniatis; S G Kee; A Efstratiadis; F C Kafatos
Journal: Cell Date: 1976-06 Impact factor: 41.582

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Authors: G Matsuda; H Takei; K C Wu; T Shiozawa
Journal: Int J Protein Res Date: 1971

10. Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules.

Authors: W Bender; N Davidson
Journal: Cell Date: 1976-04 Impact factor: 41.582

28 in total

1. Characteristics of an "unclonable" DNA sequence located in the intergenic spacer between the pi- and alpha D-globin genes of the chicken.

Authors: E S Yudinkova; E N Trifonov; K Sherrer; S V Razin
Journal: Dokl Biochem Biophys Date: 2001 May-Jun Impact factor: 0.788

2. Organization of specific DNA sequence elements in the region of the replication origin and matrix attachment site in the chicken alpha-globin gene domain.

Authors: W A Krajewski; S V Razin
Journal: Mol Gen Genet Date: 1992-11

3. Transcription of the alpha globin gene domain in normal and AEV-transformed chicken erythroblasts: mapping of giant globin-specific RNA including embryonic and adult genes.

Authors: F Broders; K Scherrer
Journal: Mol Gen Genet Date: 1987-09

4. Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

Authors: Jim R Hughes; Jan-Fang Cheng; Nicki Ventress; Shyam Prabhakar; Kevin Clark; Eduardo Anguita; Marco De Gobbi; Pieter de Jong; Eddy Rubin; Douglas R Higgs
Journal: Proc Natl Acad Sci U S A Date: 2005-07-05 Impact factor: 11.205

5. Precise localization of the alpha-globin gene cluster within one of the 20- to 300-kilobase DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase II sites in vivo: evidence that the fragments are DNA loops or domains.

Authors: S V Razin; P Petrov; R Hancock
Journal: Proc Natl Acad Sci U S A Date: 1991-10-01 Impact factor: 11.205

6. Mapping of structural and transcription-related matrix attachment sites in the alpha-globin gene domain of avian erythroblasts and erythrocytes.

Authors: G Farache; S V Razin; J Rzeszowska-Wolny; J Moreau; F R Targa; K Scherrer
Journal: Mol Cell Biol Date: 1990-10 Impact factor: 4.272

7. Organization of the 3'-boundary of the chicken alpha globin gene domain and characterization of a CR 1-specific protein binding site.

Authors: G Farache; S V Razin; F R Targa; K Scherrer
Journal: Nucleic Acids Res Date: 1990-02-11 Impact factor: 16.971