Literature DB >> 6248035

Novel inhibitors of poly(ADP-ribose) synthetase.

M R Purnell, W J Whish.   

Abstract

In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6248035      PMCID： PMC1161458          DOI： 10.1042/bj1850775

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Specific inhibition of poly adpribose polymerase by thymidine and nicotinamide in HeLa cells.

Authors:  J Preiss; R Schlaeger; H Hilz
Journal:  FEBS Lett       Date:  1971-12-15       Impact factor: 4.124

Review 2.  Poly(ADP-ribose) and ADP-ribosylation of proteins.

Authors:  O Hayaishi; K Ueda
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

Review 3.  Poly(ADP-ribose) and ADP-ribosylation of proteins.

Authors:  H Hilz; P Stone
Journal:  Rev Physiol Biochem Pharmacol       Date:  1976       Impact factor: 5.545

4.  Affinity chromatography of nuclear enzymes.

Authors:  M G Khan; S Shall
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

5.  The effect of phenones on poly(adenosine diphosphate ribose) synthetase from porcine thymus [proceedings].

Authors:  M R Purnell; W J Whish
Journal:  Biochem Soc Trans       Date:  1980-04       Impact factor: 5.407

6.  Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide.

Authors:  J B Clark; G M Ferris; S Pinder
Journal:  Biochim Biophys Acta       Date:  1971-04-29

7.  Enzymes of poly(ADPR) metabolism in proliferating and nonproliferating liver tissues.

Authors:  U Leiber; M Kittler; H Hilz
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973 Oct-Nov

8.  A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250.

Authors:  J J Sedmak; S E Grossberg
Journal:  Anal Biochem       Date:  1977-05-01       Impact factor: 3.365

Review 9.  ADP-ribosylation of nuclear proteins.

Authors:  M R Purnell; P R Stone; W J Whish
Journal:  Biochem Soc Trans       Date:  1980-04       Impact factor: 5.407

10.  Deoxyribonucleotide pools in mouse-fibroblast cell lines with altered ribonucleotide reductase.

Authors:  M Meuth; E Aufreiter; P Reichard
Journal:  Eur J Biochem       Date:  1976-12
View more
  101 in total

1.  Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity.

Authors:  M Watanabe; T Kono; Y Matsushima-Hibiya; T Kanazawa; N Nishisaka; T Kishimoto; K Koyama; T Sugimura; K Wakabayashi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

2.  Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor alpha is prevented by inhibitors of poly(ADP-ribose) polymerase.

Authors:  S Hauschildt; P Scheipers; W G Bessler; A Mülsch
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

3.  Structural requirements for inhibitors of poly(ADP-ribose) polymerase.

Authors:  P Sestili; G Spadoni; C Balsamini; I Scovassi; F Cattabeni; E Duranti; O Cantoni; D Higgins; C Thomson
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

4.  Induction of homologous recombination following in utero exposure to DNA-damaging agents.

Authors:  Bijal Karia; Jo Ann Martinez; Alexander J R Bishop
Journal:  DNA Repair (Amst)       Date:  2013-09-10

5.  Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia.

Authors:  Sankaranarayanan Kannan; Marisa J L Aitken; Shelley M Herbrich; Leonard S Golfman; Mandy G Hall; Duncan H Mak; Jared K Burks; Guangchun Song; Marina Konopleva; Charles G Mullighan; Joya Chandra; Patrick A Zweidler-McKay
Journal:  Mol Cancer Ther       Date:  2019-06-21       Impact factor: 6.261

6.  Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

Authors:  Junjie U Guo; Yijing Su; Chun Zhong; Guo-li Ming; Hongjun Song
Journal:  Cell       Date:  2011-04-14       Impact factor: 41.582

7.  Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation).

Authors:  A S Waldman; B C Waldman
Journal:  Nucleic Acids Res       Date:  1991-11-11       Impact factor: 16.971

8.  In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins.

Authors:  L Kma; R N Sharan
Journal:  Mol Cell Biochem       Date:  2006-04-01       Impact factor: 3.396

9.  Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges.

Authors:  R Saffhill; C H Ockey
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316

10.  Post-irradiation sensitization with the ADP-ribosyltransferase inhibitor 3-acetamidobenzamide.

Authors:  J Lunec; A M George; M Hedges; W A Cramp; W J Whish; B Hunt
Journal:  Br J Cancer Suppl       Date:  1984
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.