Literature DB >> 6246995

Unequal crossing-over: a common basis of single alpha-globin genes in Asians and American blacks with hemoglobin-H disease.

J A Phillips, T A Vik, A F Scott, K E Young, H H Kazazian, K D Smith, V F Fairbanks, H M Koenig.   

Abstract

The alpha-globin genes of five black Americans, two Chinese, and five Filipinos with HbH disease (an alpha-thalassemia state in which there is a single functional alpha gene) were analyzed by restriction endonuclease techniques. All subjects were found to have one chromosome 16, lacking both alpha genes, and another containing a single alpha gene (--/-alpha). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single alpha gene in these individuals.

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Year:  1980        PMID： 6246995

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  12 in total

1.  Leftward deletion alpha-thalassaemia in the Saudi Arabian population.

Authors:  M A el-Hazmi
Journal:  Hum Genet       Date:  1986-11       Impact factor: 4.132

2.  Prenatal diagnosis of alpha-thalassemia by polymerase chain reaction and dual restriction enzyme analysis.

Authors:  R V Lebo; R K Saiki; K Swanson; M A Montano; H A Erlich; M S Golbus
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

3.  Extremely high frequencies of alpha-globin gene deletion in Madang and on Kar Kar Island, Papua New Guinea.

Authors:  P T Yenchitsomanus; K M Summers; K K Bhatia; J Cattani; P G Board
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

4.  Direct identification of sickle cell anemia by blot hybridization.

Authors:  R F Geever; L B Wilson; F S Nallaseth; P F Milner; M Bittner; J T Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

Review 5.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

6.  A leftward deletional alpha+ thalassemia found in East Sicily in conjunction with heterozygous beta-thalassemia.

Authors:  C Troungos; R Krishnamoorthy; T Lombardo; G Sortino; E Cacciola; D Labie
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Homology requirements for unequal crossing over in humans.

Authors:  A B Metzenberg; G Wurzer; T H Huisman; O Smithies
Journal:  Genetics       Date:  1991-05       Impact factor: 4.562

8.  Human alpha-globin gene expression is silenced by terminal truncation of chromosome 16p beginning immediately 3' of the zeta-globin gene.

Authors:  L Romao; F Cash; I Weiss; S Liebhaber; M Pirastu; R Galanello; A Loi; E Paglietti; P Ioannou; A Cao
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

9.  An initiation codon mutation (AUG----GUG) of the human alpha 1-globin gene. Structural characterization and evidence for a mild thalassemic phenotype.

Authors:  P Moi; F E Cash; S A Liebhaber; A Cao; M Pirastu
Journal:  J Clin Invest       Date:  1987-11       Impact factor: 14.808

10.  Genomic disorders ten years on.

Authors:  James R Lupski
Journal:  Genome Med       Date:  2009-04-24       Impact factor: 11.117
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