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Literature DB >> 6246537

Beta-Endorphin: dissociation of receptor binding activity from analgesic potency.

C H Li, L F Tseng, P Ferrara, D Yamashiro.

Abstract

Biological activities of synthetic camel beta-endorphin and human beta-endorphin (beta h-EP) have been measured by the radioreceptor binding assay, using [Tyr27-3H]-beta h-EP as the primary ligand and by the tail-flick test for analgesic potency. Four synthetic analogs of beta h-EP, namely [Gly31]-beta h-EP-Gly-NH2, [Gly31]-beta h-EP-Gly-Gly-NH2, [Gln8,Gly31]-beta h-EP-Gly-Gly-NH2, and [CH3(CH2)4NH231]-beta h-EP, have also been assayed by the same procedures. Results indicate a clear dissociation of radioreceptor binding activity from analgesic potency.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6246537 PMCID： PMC348702 DOI： 10.1073/pnas.77.4.2303

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

11 in total

4. Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion.

Authors: P Nicolas; R G Hammonds; C H Li
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

4 in total

Beta-Endorphin: dissociation of receptor binding activity from analgesic potency.

1. beta-Endorphin: characteristics of binding sites in the rat brain.

2. Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

3. The synthesis and opiate activity of beta-endorphin.

4. Isolation, characterization and opiate activity of beta-endorphin from human pituitary glands.

5. Beta-Endorphin as a potent analgesic by intravenous injection.

6. Pharmacological and immunological characterization of the Leu5 analogue of human beta-endorphin.

7. beta-endorphin is a potent analgesic agent.

8. Synthesis and analgesic activity of human beta-endorphin.

9. Beta-Endorphin: lack of correlation between opiate activity and immunoreactivity by radioimmunoassay.

10. Preparation and properties of tritiated human beta-endorphin with high specific radioactivity.

1. beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.

2. beta-Endorphin: characteristics of binding sites in rabbit spinal cord.

3. beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities.

4. Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion.