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Literature DB >> 624547

Effects of caffeine on sister chromatid exchange (SCE) after exposure to UV light or triaziquone studied with a fluorescence plus giemsa (FPG) technique.

Abstract

Studies are reported that are designed to analyze the mechanism by which caffeine reduces the induction of SCE by UV light or alkylating agents. The substantial points are (1) caffeine does not inhibit SCE formation, and (2) the caffeine-mediated apparent decrease of SCE induction after UV or triaziquone exposure is due to a selective destruction of those metaphases otherwise exhibiting a high number of SCE. These findings and their relevance to the ascertainment of the SCE-forming process are discussed.

Entities: Chemical

Mesh：

Substances：
Caffeine
Triaziquone

Year: 1978 PMID： 624547 DOI： 10.1007/bf00272300

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.

Authors: D E Comings
Journal: Humangenetik Date: 1975-07-23

2. Laser UV microirradiation of interphase nuclei and post-treatment with caffeine. A new approach to establish the arrangement of interphase chromosomes.

Authors: C Zorn; T Cremer; C Cremer; J Zimmer
Journal: Hum Genet Date: 1976-12-29 Impact factor: 4.132

9. Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair.

Authors: S Wolff; J Bodycote; G H Thomas; J E Cleaver
Journal: Genetics Date: 1975-10 Impact factor: 4.562

Effects of caffeine on sister chromatid exchange (SCE) after exposure to UV light or triaziquone studied with a fluorescence plus giemsa (FPG) technique.

1. Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.

2. Laser UV microirradiation of interphase nuclei and post-treatment with caffeine. A new approach to establish the arrangement of interphase chromosomes.

3. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.

4. Induction of sister chromatid exchanges by UV light and its inhibition by caffeine.

5. Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair.

6. Recombinational DNA repair and sister chromatid exchanges.

7. Mechanisms for sister chromatid exchanges and their relation to the production of chromosomal aberrations.

8. Differential Giemsa staining of sister chromatids and the study of chromatid exchanges without autoradiography.

9. Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair.

10. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

Review 1. Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

2. Enhancement by caffeine of sister-chromatid exchange frequency induced by antineoplastic agents in human lymphocytes.

3. A schedule to demonstrate radiation-induced sister chromatid exchanges in human lymphocytes.