Literature DB >> 624362

Aflatoxin metabolism and absence of cytochrome P-450 in rat colon tissue during vitamin A malnutrition.

A A Adekunle, T C Campbell, S C Campbell.   

Abstract

Homogenized mucosal linings prepared from vitamin A adequate and deficient male rats were used in metabolic studies of aflatoxin B1 (AFB1). Cytochrome P-420 was identified in both groups which metabolized AFB1 to 4 metabolic products in vitro. The implications of this observation are discussed in relation to colon carcinoma.

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Year:  1978        PMID： 624362     DOI： 10.1007/bf01944697

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Two new metabolites of Aspergillus flavus (Link).

Authors:  O Bassir; A Adekunle
Journal:  FEBS Lett       Date:  1968-11       Impact factor: 4.124

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

3.  Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.

Authors:  J B Neeld; W N Pearson
Journal:  J Nutr       Date:  1963-04       Impact factor: 4.798

4.  Pigments of rat liver microsomes.

Authors:  M KLINGENBERG
Journal:  Arch Biochem Biophys       Date:  1958-06       Impact factor: 4.013

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizng enzyme system. II. Effect of enzyme kinetics and electron transport system.

Authors:  M U Mgbodile; J R Hayes; T C Campbell
Journal:  Biochem Pharmacol       Date:  1973-05-15       Impact factor: 5.858

7.  Microsomal hydroxylases: induction and role in polycyclic hydrocarbon carcinogenesis and toxicity.

Authors:  H V Gelboin; N Kinoshita; F J Wiebel
Journal:  Fed Proc       Date:  1972 Jul-Aug

8.  Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system. I. Effect on substrate interaction with cytochrome P-450.

Authors:  J R Hayes; M U Mgbodile; T C Campbell
Journal:  Biochem Pharmacol       Date:  1973-05-01       Impact factor: 5.858

9.  Rat colon carcinomas associated with aflatoxin and marginal vitamin A.

Authors:  P M Newberne; A E Rogers
Journal:  J Natl Cancer Inst       Date:  1973-02       Impact factor: 13.506

10.  The effect of quantity and quality of dietary protein on drug metabolism.

Authors:  T C Campbell; J R Hayes
Journal:  Fed Proc       Date:  1976-11
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  1 in total

1.  Effect of vitamin A deficiency on rat hepatic and colon epoxide hydrase.

Authors:  A A Adekunle; T C Campbell; S C Campbell
Journal:  Experientia       Date:  1979-02-15
  1 in total

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