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Literature DB >> 6243610

Adjuvant effects of amorphous silica and of aluminium hydroxide on IgE and IgG1 antibody production in different inbred mouse strains.

Abstract

The adjuvant effects of an amorphous silica (Aerosil) and of A1(OH)3 on primary and secondary IgE and IgG1 immune responses to small doses of OA were studied comparatively in BALB/c, C57BL, DBA/1, AKR, DBA/2 and SJL inbred mouse strains. During the primary response, all mouse strains produced both IgG1 and IgE antibodies when antigen was given with A1(OH)3, whereas only DBA/1, BALB/c and DBA/2 mice produced IgG1 and/or IgE antibodies when Aerosil was used as the adjuvant. A booster effect, higher than that obtained by A1(OH)3, was induced by Aerosil in all mouse strains. The adjuvant effect of Aerosil was more selectively directed to the production of IgE antibody.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6243610 DOI： 10.1159/000232443

Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915

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Cited

8 in total

1. C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responses.

Authors: T Morokata; J Ishikawa; K Ida; T Yamada
Journal: Immunology Date: 1999-11 Impact factor: 7.397

2. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation.

Authors: J W Mannhalter; H O Neychev; G J Zlabinger; R Ahmad; M M Eibl
Journal: Clin Exp Immunol Date: 1985-07 Impact factor: 4.330

3. Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins.

Authors: J Van Ness; U K Laemmli; D E Pettijohn
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

4. Immunization of mouse spleen cell cultures in the absence of serum and its proteins using SiO2 and 2-mercaptoethanol.

Authors: M Burger
Journal: Immunology Date: 1982-02 Impact factor: 7.397

5. Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique.

Authors: Vanessa Neuhaus; Katharina Schwarz; Anna Klee; Sophie Seehase; Christine Förster; Olaf Pfennig; Danny Jonigk; Hans-Gerd Fieguth; Wolfgang Koch; Gregor Warnecke; Vidadi Yusibov; Katherina Sewald; Armin Braun
Journal: PLoS One Date: 2013-08-13 Impact factor: 3.240

Adjuvant effects of amorphous silica and of aluminium hydroxide on IgE and IgG1 antibody production in different inbred mouse strains.

1. C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responses.

2. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation.

3. Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins.

4. Immunization of mouse spleen cell cultures in the absence of serum and its proteins using SiO2 and 2-mercaptoethanol.

5. Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique.

6. The importance of leukotrienes in airway inflammation in a mouse model of asthma.

7. Silica nanoparticles as the adjuvant for the immunisation of mice using hepatitis B core virus-like particles.

8. Influence of Asian dust particles on immune adjuvant effects and airway inflammation in asthma model mice.