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Literature DB >> 6242420

Chemosensitivity tests by a miniclone technique.

Abstract

A modified miniclone method has been adopted to tissue culture testing of sensitivity to cytostatic drugs. The technique permits detailed microscopic clonal analysis of multiplication of single cells under conditions of 100% plating efficiency of certain selected established tumor lines or normal cells. Three different response parameters were distinguished--cytolysis, cytostasis and replicative capacity of cell fraction capable of multiplication. Notable differences were found among the five drugs tested--adriamycin, alkeran, BCNU, platinol and streptozocin.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6242420 DOI： 10.1007/bf02935321

Source DB: PubMed Journal: Med Oncol Tumor Pharmacother ISSN： 0736-0118

5 in total

3 in total

Review 1. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. II. Assay methods, adriamycin and the other antitumour antibiotics.

Authors: A G Bosanquet
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

Review 2. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents.

Authors: A G Bosanquet
Journal: Cancer Chemother Pharmacol Date: 1989 Impact factor: 3.333

Review 3. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.

Authors: A G Bosanquet
Journal: Cancer Chemother Pharmacol Date: 1985 Impact factor: 3.333

3 in total

Chemosensitivity tests by a miniclone technique.

1. An improved nutrient solution for diploid Chinese hamster and human cell lines.

2. Growth control in miniclones of human glial cells.

3. Proliferation control in cloned normal and malignant human cells.

4. Primary bioassay of human tumor stem cells.

5. The usefulness of human tumor cell lines in the study of chemosensitivity. A study of malignant melanomas.

Review 1. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. II. Assay methods, adriamycin and the other antitumour antibiotics.

Review 2. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents.

Review 3. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.