Literature DB >> 6240987

Effects of antidepressants on skilled performance.

M Linnoila, J Johnson, K Dubyoski, M S Buchsbaum, M Schneinin, C Kilts.   

Abstract

Effects of amitriptyline 50 mg, desipramine 100 mg, and zimelidine 200 mg alone and in combination with ethanol 0.8 g/kg were investigated in healthy, male volunteers. Amitriptyline increased body sway and impaired tracking as well as information processing. It had an additive deleterious pharmacodynamic interaction with ethanol. Desipramine and zimelidine were free of adverse effects on performance and did not have significant interactions with ethanol. The dose of ethanol used in the present study did not inhibit biotransformation of the antidepressants.

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Year:  1984        PMID： 6240987      PMCID： PMC1463331          DOI： 10.1111/j.1365-2125.1984.tb02589.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  4 in total

1.  High-performance liquid chromatographic assay for imipramine, desipramine, and their 2-hydroxylated metabolites.

Authors:  T A Sutfin; W J Jusko
Journal:  J Pharm Sci       Date:  1979-06       Impact factor: 3.534

2.  Drinking and driving in 753 general practice and psychiatric patients on psychotropic drugs.

Authors:  G Milner
Journal:  Br J Psychiatry       Date:  1969-01       Impact factor: 9.319

3.  Effects of alcohol on psychomotor performance of men and women.

Authors:  M Linnoila; C W Erwin; W P Cleveland; P E Logue; W D Gentry
Journal:  J Stud Alcohol       Date:  1978-05

4.  Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction.

Authors:  P Dorian; E M Sellers; K L Reed; J J Warsh; C Hamilton; H L Kaplan; T Fan
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953
  4 in total
  5 in total

Review 1.  The effects of fall-risk-increasing drugs on postural control: a literature review.

Authors:  Maartje H de Groot; Jos P C M van Campen; Marije A Moek; Linda R Tulner; Jos H Beijnen; Claudine J C Lamoth
Journal:  Drugs Aging       Date:  2013-11       Impact factor: 3.923

Review 2.  Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol).

Authors:  Lingtak-Neander Chan; Gail D Anderson
Journal:  Clin Pharmacokinet       Date:  2014-12       Impact factor: 6.447

Review 3.  Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects.

Authors:  G J H Dumont; S J de Visser; A F Cohen; J M A van Gerven
Journal:  Br J Clin Pharmacol       Date:  2005-05       Impact factor: 4.335

4.  Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.

Authors:  M Linnoila; J M Stapleton; R Lister; H Moss; E Lane; A Granger; M J Eckardt
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

5.  Effects of adinazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.

Authors:  M Linnoila; J M Stapleton; R Lister; H Moss; E Lane; A Granger; D J Greenblatt; M J Eckardt
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953
  5 in total

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