Literature DB >> 458567

High-performance liquid chromatographic assay for imipramine, desipramine, and their 2-hydroxylated metabolites.

T A Sutfin, W J Jusko.   

Abstract

High-performance liquid chromatographic method is presented for the simultaneous determination of imipramine, desipramine, and their 2-hydroxylated metabolites in plasma. The method involves a simple plasma extraction at basic pH with organic solvent, chromatography on a silica gel column, and fluorescence detection. Correlation with a GLC-mass spectrometric method for imipramine and desipramine is illustrated. The method can detect 1 ng of each component/ml of plasma, sufficient sensitivity for pharmocokinetic studies.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 458567     DOI： 10.1002/jps.2600680612

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  11 in total

1.  Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study.

Authors:  E Spina; C Gitto; A Avenoso; G M Campo; A P Caputi; E Perucca
Journal:  Eur J Clin Pharmacol       Date:  1997       Impact factor: 2.953

2.  Quantification of imipramine and its major metabolites in whole blood, brain, and other tissues of the rat by liquid chromatography.

Authors:  S A Stout; C L DeVane
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  The analysis and disposition of imipramine and its active metabolites in man.

Authors:  T A Sutfin; C L DeVane; W J Jusko
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat.

Authors:  C L DeVane; J W Simpkins; S A Stout
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

5.  Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Authors:  M V Rudorfer; E A Lane; W H Chang; M D Zhang; W Z Potter
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

Review 6.  Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline.

Authors:  C Nordin; L Bertilsson
Journal:  Clin Pharmacokinet       Date:  1995-01       Impact factor: 6.447

7.  Effects of antidepressants on skilled performance.

Authors:  M Linnoila; J Johnson; K Dubyoski; M S Buchsbaum; M Schneinin; C Kilts
Journal:  Br J Clin Pharmacol       Date:  1984       Impact factor: 4.335

Review 8.  Clinical pharmacokinetics of drugs used to treat urge incontinence.

Authors:  David R P Guay
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

9.  The effect of carbamazepine on the 2-hydroxylation of desipramine.

Authors:  E Spina; A Avenoso; G M Campo; A P Caputi; E Perucca
Journal:  Psychopharmacology (Berl)       Date:  1995-02       Impact factor: 4.530

10.  Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes.

Authors:  E Spina; Y Koike
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.