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Literature DB >> 6239682

In vitro effects of 4-hydroperoxycyclophosphamide on concanavalin A-induced human suppressor T cells.

A Klajman, I Drucker, Y Manor, S Ben-Efraim.

Abstract

Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) before incubation with ConA markedly decreased the generation of suppressor cells by ConA. The effect of 4-HPCy on generation of suppressor cells was more pronounced in the test of ConA stimulation than in the MLR. Treatment with 4-HPCy had no effect on suppressor cells already induced as shown by incubation of PBL with 4-HPCy after incubation with ConA.

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Year: 1984 PMID： 6239682 DOI： 10.1007/bf00205744

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968

11 in total

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Authors: J L'age-Stehr; T Diamanstein
Journal: Nature Date: 1978-02-16 Impact factor: 49.962

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Authors: F L Shand; J G Howard
Journal: Eur J Immunol Date: 1979-01 Impact factor: 5.532

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Journal: Int J Immunopharmacol Date: 1979

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Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

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Authors: H K Gill; F Y Liew
Journal: Eur J Immunol Date: 1978-03 Impact factor: 5.532

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Authors: S H Kaufmann; H Hahn; T Diamantstein
Journal: J Immunol Date: 1980-09 Impact factor: 5.422

7. Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamide of antigen-primed T cells regulating humoral and cell-mediated immune responses to sheep erythrocytes: a possible explanation for the inverse action of cyclophosphamide on humoral and cell-mediated immune responses.

Authors: T Diamantstein; M Klos; H Hahn; S H Kaufmann
Journal: J Immunol Date: 1981-05 Impact factor: 5.422

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Authors: L Shou; S A Schwartz; R A Good
Journal: J Exp Med Date: 1976-05-01 Impact factor: 14.307

9. In vitro effects of 4-hydroperoxycyclophosphamide on human immunoregulatory T subset function. I. Selective effects on lymphocyte function in T-B cell collaboration.

Authors: H Ozer; J W Cowens; M Colvin; A Nussbaum-Blumenson; D Sheedy
Journal: J Exp Med Date: 1982-01-01 Impact factor: 14.307

4. The difference between 5-fluorouracil and melphalan in their ability to promote antitumor immune response against MOPC-315 plasmacytoma.

Authors: S Ben-Efraim; S Shoval; R Ophir
Journal: Cancer Immunol Immunother Date: 1986 Impact factor: 6.968

5. Inhibition of T suppressor cell function by local administration of an active cyclophosphamide derivative at the sensitization site.

Authors: J Limpens; R J Scheper
Journal: Clin Exp Immunol Date: 1991-06 Impact factor: 4.330

5 in total