Literature DB >> 1117258

Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.

P W Askenase, B J Hayden, R K Gershon.   

Abstract

Mice immunized with more SRBC than are required to produce optimal delayed-type hypersensitivity reactions, developed good antibody responses and poor delayed foot pad reactions. Cyclophosphamide treatment in low doses (20 mg/kg) before immunization, augmented the delayed-type hypersensitivity without affecting antibody responses. Cyclophosphamide did not augment delayed responses to optimal doses of SRBC (0.01%), but did augment the delayed hypersensitivity response of mice immunized with a suboptimal antigen dose (0.001%); which produced no detectable antibody response with or without cyclophosphamide pretreatment. These results suggest that antibody feedback is not the sole regulator of delayed reactions; the possibility that suppressor T cells may also be involved is discussed.

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Year:  1975        PMID： 1117258      PMCID： PMC2189708          DOI： 10.1084/jem.141.3.697

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.

Authors:  B BENACERRAF; P G GELL
Journal:  Immunology       Date:  1959-01       Impact factor: 7.397

2.  Influence of dose and route of antigen injection on the immunological induction of T cells.

Authors:  P H Lagrange; G B Mackaness; T E Miller
Journal:  J Exp Med       Date:  1974-03-01       Impact factor: 14.307

3.  Preferential induction of cell-mediated immunity by chemically modified sheep erythrocytes.

Authors:  C R Parish
Journal:  Eur J Immunol       Date:  1972-04       Impact factor: 5.532

4.  Activation of suppressor T cells by tumour cells and specific antibody.

Authors:  R K Gershon; M B Mokyr; M S Mitchell
Journal:  Nature       Date:  1974-08-16       Impact factor: 49.962

5.  Subpopulations of mouse T lymphocytes. I. "Thymidine suicide" of a major proliferating, PHA-responsive cell population present in spleen but not in lymph node.

Authors:  J W Moorhead; H N Claman
Journal:  J Immunol       Date:  1974-01       Impact factor: 5.422

6.  Delayed hypersensitivity: is the same population of thymus-derived cells responsible for cellular immunity reactions and the carrier effect?

Authors:  J Kettman
Journal:  Immunol Commun       Date:  1972

7.  Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity.

Authors:  L Polak; J L Turk
Journal:  Nature       Date:  1974-06-14       Impact factor: 49.962

8.  Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide.

Authors:  J L Turk; D Parker; L W Poulter
Journal:  Immunology       Date:  1972-10       Impact factor: 7.397

9.  Feedback inhibition of specifically sensitized lymphocytes.

Authors:  G B Mackaness; P H Lagrange; T E Miller; T Ishibashi
Journal:  J Exp Med       Date:  1974-03-01       Impact factor: 14.307

10.  Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.

Authors:  P H Lagrange; G B Mackaness; T E Miller
Journal:  J Exp Med       Date:  1974-06-01       Impact factor: 14.307
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  106 in total

1.  Skin test to assess virus-specific cytotoxic T-cell activity.

Authors:  T M Kündig; A Althage; H Hengartner; R M Zinkernagel
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

2.  Preliminary result of mixed bacterial vaccine as adjuvant treatment of hepatocellular carcinoma.

Authors:  Z Y Tang; H Y Zhou; G Zhao; L M Chai; M Zhou; J Z Lu; K D Liu; H F Havas; H C Nauts
Journal:  Med Oncol Tumor Pharmacother       Date:  1991

3.  Renal cell carcinoma treated by vaccines for active specific immunotherapy: correlation of survival with skin testing by autologous tumor cells.

Authors:  C S McCune; R W O'Donnell; D M Marquis; D M Sahasrabudhe
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

4.  Titration and circulation of cells mediating delayed type hypersensitivity in normal and cyclophosphamide treated mice during response to sheep red blood cells.

Authors:  G Marchal; G Milon; B Hurtrel; P H Lagrance
Journal:  Immunology       Date:  1978-12       Impact factor: 7.397

5.  Relationship between delayed hypersensitivity response and acquired cell-mediated immunity in C57BL/6J mice infected with Leishmania donovani.

Authors:  J R Fahey; R Herman
Journal:  Infect Immun       Date:  1985-08       Impact factor: 3.441

6.  Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle.

Authors:  M N Hart; S K Tassell; K L Sadewasser; R L Schelper; S A Moore
Journal:  Am J Pathol       Date:  1985-06       Impact factor: 4.307

7.  Effect of cyclophosphamide on delayed hypersensitivity to Staphylococcus aureus in mice.

Authors:  C S Easmon; A A Glynn
Journal:  Immunology       Date:  1977-11       Impact factor: 7.397

8.  Regulation of resistance against adjuvant arthritis in the Fisher rat.

Authors:  A G van de Langerijt; P L van Lent; A R Hermus; L B van de Putte; W B van den Berg
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

9.  Regulation of the immune response to tumor antigen.

Authors:  M I Greene; L L Perry; B Benacerraf
Journal:  Am J Pathol       Date:  1979-04       Impact factor: 4.307

10.  Effect of cyclophosphamide treatment on the course of Mycobacterium lepraemurium infection and development of delayed-type hypersensitivity reactions in C57B1 and BALB/c mice.

Authors:  J Alexander
Journal:  Clin Exp Immunol       Date:  1978-10       Impact factor: 4.330
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