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Literature DB >> 623862

Experimental evidence for the role of cross-relaxation in proton nuclear magnetic resonance spin lattice relaxation time measurements in proteins.

Abstract

Proton nuclear magnetic resonance (NMR) spin lattice relaxation time (T1) and spin-spin relaxation time (T2) measurements are presented for a number of proteins with molecular weights spanning the range of 6,500-150,000 daltons. These measurements provide experimental evidence for the role of cross-relaxation in 1H NMR T1 measurements in proteins. The relationship between these measurements and the theory recently presented by Kalk and Berendsen is discussed. The results indicate that cross-relaxation dominates the T1 measurements for the larger proteins, even at relatively low resonance frequencies such as 100 MHz.

Entities: Chemical

Mesh：

Substances：
Proteins
Protons

Year: 1978 PMID： 623862 PMCID： PMC1473348 DOI： 10.1016/S0006-3495(78)85514-3

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

9 in total

1. Concanavalin A: a stopped flow nuclear magnetic resonance study of conformational changes induced by Mn++, Ca++, and alpha-methyl-D-mannoside.

Authors: J J Grimaldi; B D Sykes
Journal: J Biol Chem Date: 1975-03-10 Impact factor: 5.157

2. Fluorotyrosine alkaline phosphatase: internal mobility of individual tyrosines and the role of chemical shift anisotropy as a 19F nuclear spin relaxation mechanism in proteins.

Authors: W E Hull; B D Sykes
Journal: J Mol Biol Date: 1975-10-15 Impact factor: 5.469

3. Complete tyrosine assignments in the high field 1H nuclear magnetic resonance spectrum of the bovine pancreatic trypsin inhibitor.

Authors: G H Snyder; R Rowan; S Karplus; B D Sykes
Journal: Biochemistry Date: 1975-08-26 Impact factor: 3.162

4. Subunit structure of aspartate transcarbamylase from Escherichia coli.

Authors: J P Rosenbusch; K Weber
Journal: J Biol Chem Date: 1971-03-25 Impact factor: 5.157

5. Kinetics of the interaction of methyl isonitrile with hemoglobin beta chains: measurement by nuclear magnetic resonance.

Authors: B A Manuck; J G Maloney; B D Sykes
Journal: J Mol Biol Date: 1973-12-05 Impact factor: 5.469

6. Effect of internal rotation on nuclear magnetic relaxation times for macromolecules.

Authors: A G Marshall; P G Schmidt; B D Sykes
Journal: Biochemistry Date: 1972-10-10 Impact factor: 3.162

7. Cross relaxation and spin diffusion in the proton NMR or hydrated collagen.

Authors: H T Edzes; E T Samulski
Journal: Nature Date: 1977-02-10 Impact factor: 49.962

8. Molecular dynamics and structure of the random coil and helical states of the collagen peptide, alpha 1-CB2, as determined by 13C magnetic resonance.

Authors: D A Torchia; J R Lyerla; A J Quattrone
Journal: Biochemistry Date: 1975-03-11 Impact factor: 3.162

9. Fluorotyrosine alkaline phosphatase from Escherichia coli: preparation, properties, and fluorine-19 nuclear magnetic resonance spectrum.

Authors: B D Sykes; H I Weingarten; M J Schlesinger
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

9 in total

1. Characterization of an artificial dimer of ribonuclease H using 1H NMR spectroscopy.

Authors: D Yang; K Yamamoto; E Kanaya; S Kanaya; K Nagayama
Journal: J Biomol NMR Date: 1996-01 Impact factor: 2.835

2. A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle.

Authors: Gili Abramov; Algirdas Velyvis; Enrico Rennella; Leo E Wong; Lewis E Kay
Journal: Proc Natl Acad Sci U S A Date: 2020-05-26 Impact factor: 11.205

3. Proton longitudinal relaxation investigation of histidyl residues of normal human adult and sickle deoxyhemoglobin: evidence for the existence of pregelation aggregates in sickle deoxyhemoglobin solutions.

Authors: I M Russu; C Ho
Journal: Proc Natl Acad Sci U S A Date: 1980-11 Impact factor: 11.205

7. Amide proton spin-lattice relaxation in polypeptides. A field-dependence study of the proton and nitrogen dipolar interactions in alumichrome.

Authors: M Llinás; M P Klein; K Wüthrich
Journal: Biophys J Date: 1978-12 Impact factor: 4.033

8. Protein-Inhibitor Interaction Studies Using NMR.

Authors: Rieko Ishima
Journal: Appl NMR Spectrosc Date: 2015

9. Nuclear Overhauser effect and cross-relaxation rate determinations of dihedral and transannular interproton distances in the decapeptide tyrocidine A.

Authors: M C Kuo; W A Gibbons
Journal: Biophys J Date: 1980-11 Impact factor: 4.033

9 in total

Experimental evidence for the role of cross-relaxation in proton nuclear magnetic resonance spin lattice relaxation time measurements in proteins.

1. Concanavalin A: a stopped flow nuclear magnetic resonance study of conformational changes induced by Mn++, Ca++, and alpha-methyl-D-mannoside.

2. Fluorotyrosine alkaline phosphatase: internal mobility of individual tyrosines and the role of chemical shift anisotropy as a 19F nuclear spin relaxation mechanism in proteins.

3. Complete tyrosine assignments in the high field 1H nuclear magnetic resonance spectrum of the bovine pancreatic trypsin inhibitor.

4. Subunit structure of aspartate transcarbamylase from Escherichia coli.

5. Kinetics of the interaction of methyl isonitrile with hemoglobin beta chains: measurement by nuclear magnetic resonance.

6. Effect of internal rotation on nuclear magnetic relaxation times for macromolecules.

7. Cross relaxation and spin diffusion in the proton NMR or hydrated collagen.

8. Molecular dynamics and structure of the random coil and helical states of the collagen peptide, alpha 1-CB2, as determined by 13C magnetic resonance.

9. Fluorotyrosine alkaline phosphatase from Escherichia coli: preparation, properties, and fluorine-19 nuclear magnetic resonance spectrum.

1. Characterization of an artificial dimer of ribonuclease H using 1H NMR spectroscopy.

2. A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle.

3. Proton longitudinal relaxation investigation of histidyl residues of normal human adult and sickle deoxyhemoglobin: evidence for the existence of pregelation aggregates in sickle deoxyhemoglobin solutions.

4. Proton longitudinal relaxation investigation of histidyl residues in human normal adult hemoglobin.

5. The orientation and dynamics of substance P in lipid environments.

6. R1ρ sensitivity to pH and other compounds at clinically accessible spin-lock fields in the presence of proteins.

7. Amide proton spin-lattice relaxation in polypeptides. A field-dependence study of the proton and nitrogen dipolar interactions in alumichrome.

8. Protein-Inhibitor Interaction Studies Using NMR.

9. Nuclear Overhauser effect and cross-relaxation rate determinations of dihedral and transannular interproton distances in the decapeptide tyrocidine A.