Literature DB >> 6237365

Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules.

T W Redding, A V Schally, T R Tice, W E Meyers.   

Abstract

Intramuscular injection of [6-D-tryptophan]-luteinizing hormone-releasing hormone [( D-Trp6]LH-RH) in microcapsules of poly(DL-lactide-co-glycolide), designed to release a controlled dose of the peptide over a 30-day period, decreased the weights of androgen-dependent Dunning prostate tumors in rats and suppressed serum testosterone levels more effectively than daily subcutaneous administration of equivalent or double doses of unencapsulated [D-Trp6]LH-RH. The microcapsules or daily injections of [D-Trp6]LH-RH also significantly decreased tumor volumes. Microcapsules of [D-Trp6]LH-RH or related analogs that can be injected once a month should make the treatment of patients with prostate carcinoma and other neoplasms or disorders more convenient and efficacious.

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Year:  1984        PMID： 6237365      PMCID： PMC391808          DOI： 10.1073/pnas.81.18.5845

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  New long-acting injectable microcapsule contraceptive system.

Authors:  L R Beck; D R Cowsar; D H Lewis; J W Gibson; C E Flowers
Journal:  Am J Obstet Gynecol       Date:  1979-10-01       Impact factor: 8.661

2.  Potent inhibitory activity of [D-Leu6, Des-Gly-NH2(10)]LHRH ethylamide on LH/hCG and PRL testicular receptor levels in the rat.

Authors:  C Auclair; P A Kelly; D H Coy; A V Schally; F Labrie
Journal:  Endocrinology       Date:  1977-12       Impact factor: 4.736

3.  The anti-reproductive pharmacology of LH-RH and agonistic analogues.

Authors:  A Corbin; C W Beattie; J Tracy; R Jones; T J Foell; J Yardley; R W Rees
Journal:  Int J Fertil       Date:  1978

4.  Characterization and comparison of the estrogen and androgen receptors from the R-3327 rat prostatic adenocarcinoma.

Authors:  F S Markland; L Lee
Journal:  J Steroid Biochem       Date:  1979-01       Impact factor: 4.292

5.  Endocrine manipulation of the Dunning prostatic adenocarcinoma.

Authors:  F S Shessel; N L Block; B Stover; A Claflin; T I Malinin; V A Politano
Journal:  Invest Urol       Date:  1980-05

6.  Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6.

Authors:  D H Coy; J A Vilchez-Martinez; E J Coy; A V Schally
Journal:  J Med Chem       Date:  1976-03       Impact factor: 7.446

7.  Pituitary gonadotropin inhibition by a highly active analog of luteinizing hormone-releasing hormone.

Authors:  J Sandow; W Von Rechenberg; G Jerzabek; W Stoll
Journal:  Fertil Steril       Date:  1978-08       Impact factor: 7.329

8.  Androgen, estrogen and progesterone receptors of the R3327H Copenhagen rat prostatic tumor.

Authors:  W D Heston; M Menon; C Tananis; P C Walsh
Journal:  Cancer Lett       Date:  1979-01       Impact factor: 8.679

9.  Delay of puberty and inhibition of reproductive processes in the rat by a gonadotropin-releasing hormone agonist analog.

Authors:  E S Johnson; R L Gendrich; W F White
Journal:  Fertil Steril       Date:  1976-07       Impact factor: 7.329

10.  Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des-Gly-NH210] LHRH ethylamide.

Authors:  G Pelletier; L Cusan; C Auclair; P A Kelly; L Désy; F Labrie
Journal:  Endocrinology       Date:  1978-08       Impact factor: 4.736
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  28 in total

1.  Treatment of tuberculosis using a combination of sustained-release rifampin-loaded microspheres and oral dosing with isoniazid.

Authors:  D C Quenelle; G A Winchester; J K Staas; E L Barrow; W W Barrow
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

2.  Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice.

Authors:  D C Quenelle; J K Staas; G A Winchester; E L Barrow; W W Barrow
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  Utilization of an amorphous form of a water-soluble GPIIb/IIIa antagonist for controlled release from biodegradable microspheres.

Authors:  S Takada; T Kurokawa; K Miyazaki; S Iwasa; Y Ogawa
Journal:  Pharm Res       Date:  1997-09       Impact factor: 4.200

4.  Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen.

Authors:  S J Challacombe; D Rahman; H Jeffery; S S Davis; D T O'Hagan
Journal:  Immunology       Date:  1992-05       Impact factor: 7.397

5.  Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate.

Authors:  H Okada; T Heya; Y Ogawa; H Toguchi; T Shimamoto
Journal:  Pharm Res       Date:  1991-05       Impact factor: 4.200

6.  Protective effects of analogs of luteinizing hormone-releasing hormone against chemotherapy-induced testicular damage in rats.

Authors:  T Karashima; A Zalatnai; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  Radioimmunoassay for 6-D-tryptophan analog of luteinizing hormone-releasing hormone: measurement of serum levels after administration of long-acting microcapsule formulations.

Authors:  M Mason-Garcia; S Vigh; A M Comaru-Schally; T W Redding; A Somogyvari-Vigh; J Horvath; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

Review 8.  Luteinizing hormone-releasing hormone and its analogues: a review of biological properties and clinical uses.

Authors:  B J Furr; J R Woodburn
Journal:  J Endocrinol Invest       Date:  1988 Jul-Aug       Impact factor: 4.256

9.  Micromethod for the determination of free and total prolactin receptors: measurement of receptor levels in normal and malignant mammary and prostate tissues.

Authors:  M Ben-David; T Kadar; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

10.  Formulation and characterization of rifampicin microcapsules.

Authors:  Md Sarfaraz; D Hiremath; K P R Chowdary
Journal:  Indian J Pharm Sci       Date:  2010-01       Impact factor: 0.975
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