Literature DB >> 369841

Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des-Gly-NH210] LHRH ethylamide.

G Pelletier, L Cusan, C Auclair, P A Kelly, L Désy, F Labrie.   

Abstract

The effect of treatment with a potent LHRH agonist, [D-Ala6, Des-Gly-NH210]LHRH ethylamide, injected at the low dose of 100 ng, twice a week, was evaluated on spermatogenesis in the rat. Significant degenerative changes of seminiferous tubules could be observed after two weeks of treatment. These changes were progressive and led to a marked inhibition of spermatogenesis after four to eight weeks of treatment. Testis weight was decreased to approximately 50% of control after eight weeks of treatment.

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Year:  1978        PMID： 369841     DOI： 10.1210/endo-103-2-641

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  7 in total

1.  Suppression of meiosis of male germ cells by an antagonist of luteinizing hormone-releasing hormone.

Authors:  B Szende; T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

2.  Sensitivity of luteinizing hormone and gonadal steroid responses to single intranasal administration of an LHRH agonist (Hoe-766) in young normal adult men.

Authors:  N Faure; F Labrie; A Belanger; A Lemay; J P Raynaud; M Von der Ohe; A T Fazekas
Journal:  J Endocrinol Invest       Date:  1982 Nov-Dec       Impact factor: 4.256

3.  Predominant suppression of follicle-stimulating hormone β-immunoreactivity after long-term treatment of intact and castrate adult male rats with the gonadotrophin-releasing hormone agonist deslorelin.

Authors:  A W Smith; C S Asa; B S Edwards; W J Murdoch; D C Skinner
Journal:  J Neuroendocrinol       Date:  2012-05       Impact factor: 3.627

4.  Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules.

Authors:  T W Redding; A V Schally; T R Tice; W E Meyers
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

5.  Direct inhibition of testicular function by gonadotropin-releasing hormone: mediation by specific gonadotropin-releasing hormone receptors in interstitial cells.

Authors:  R N Clayton; M Katikineni; V Chan; M L Dufau; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

6.  D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons.

Authors:  R W Lewis; K J Dowling; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

7.  Effect of chronic treatment with [D-Ala6, des-Gly-NH210]LHRH ethylamide on ovarian histology in the rat.

Authors:  C Séguin; G Pelletier; F Labrie
Journal:  Cell Tissue Res       Date:  1982       Impact factor: 5.249
  7 in total

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