Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.

Literature DB >> 6236746

Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.

Abstract

We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.

Entities: Chemical Species

Mesh：

Substances：

Year: 1984 PMID： 6236746 PMCID： PMC179912 DOI： 10.1128/AAC.26.1.35

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. [Clinical experiences with an intestinal disinfectant free of side-effects].

Authors: R J SCHUSTER
Journal: Wien Med Wochenschr Date: 1959-12-12

2. Bicyclomycin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity.

Authors: M Nishida; Y Mine; T Matsubara; S Goto; S Kuwahara
Journal: J Antibiot (Tokyo) Date: 1972-10 Impact factor: 2.649

3. Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12.

Authors: P S Venkateswaran; H C Wu
Journal: J Bacteriol Date: 1972-06 Impact factor: 3.490

4. [The treatment of dysbiotic intestinal disorders with Mexaform S].

Authors: L Dütsch
Journal: Med Welt Date: 1965-07-17

5. Comparative effects of synthetic and natural secretin on pancreatic secretion and on secretin, insulin, and glucagon levels in man.

Authors: C Beglinger; K Gyr; B Werth; U Keller; J Girard
Journal: Dig Dis Sci Date: 1982-03 Impact factor: 3.199

6. Antimicrobial spectrum of triclosan, a broad-spectrum antimicrobial agent for topical application. II. Comparison with some other antimicrobial agents.

Authors: J Regös; O Zak; R Solf; W A Vischer; E G Weirich
Journal: Dermatologica Date: 1979

6 in total

8 in total

Review 1. Non-immunological defence mechanisms of the gut.

Authors: S A Sarker; K Gyr
Journal: Gut Date: 1992-07 Impact factor: 23.059

2. Antimicrobial activity of human pancreatic juice and its interaction with antibiotics.

Authors: E B Minelli; A Benini; C Bassi; H Abbas; M Falconi; F Locatelli; R de Marco; P Pederzoli
Journal: Antimicrob Agents Chemother Date: 1996-09 Impact factor: 5.191

3. Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.

Authors: Gregory J Crowther; Alberto J Napuli; James H Gilligan; Kerstin Gagaring; Rachel Borboa; Carolyn Francek; Zhong Chen; Eleanor F Dagostino; Justin B Stockmyer; Yu Wang; Philip P Rodenbough; Lisa J Castaneda; David J Leibly; Janhavi Bhandari; Michael H Gelb; Achim Brinker; Ingo H Engels; Jennifer Taylor; Arnab K Chatterjee; Pascal Fantauzzi; Richard J Glynne; Wesley C Van Voorhis; Kelli L Kuhen
Journal: Mol Biochem Parasitol Date: 2010-09-15 Impact factor: 1.759

Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.

1. [Clinical experiences with an intestinal disinfectant free of side-effects].

2. Bicyclomycin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity.

3. Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12.

4. [The treatment of dysbiotic intestinal disorders with Mexaform S].

5. Comparative effects of synthetic and natural secretin on pancreatic secretion and on secretin, insulin, and glucagon levels in man.

6. Antimicrobial spectrum of triclosan, a broad-spectrum antimicrobial agent for topical application. II. Comparison with some other antimicrobial agents.

Review 1. Non-immunological defence mechanisms of the gut.

2. Antimicrobial activity of human pancreatic juice and its interaction with antibiotics.

3. Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.

4. Fleroxacin (Ro 23-6240) distribution in canine prostatic tissue and fluids.

5. Pure pancreatic juice from patients with chronic pancreatitis has an impaired antibacterial activity.

6. Antibacterial and mezlocillin-enhancing activity of pure human pancreatic fluid.

7. Influence of feeding regimen and postnatal developmental stages on antibacterial activity of pancreatic juice.

8. Potentiation of antibacterial activity of azithromycin and other macrolides by normal human serum.