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Literature DB >> 6236745

Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.

Abstract

Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.

Entities: Chemical Species

Mesh：

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Year: 1984 PMID： 6236745 PMCID： PMC179930 DOI： 10.1128/AAC.26.1.110

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.

Authors: D L Shungu; E Weinberg; H H Gadebusch
Journal: Antimicrob Agents Chemother Date: 1983-01 Impact factor: 5.191

2. In vitro antibacterial activity of norfloxacin (MK-0366).

Authors: A King; C Warren; K Shannon; I Phillips
Journal: Antimicrob Agents Chemother Date: 1982-04 Impact factor: 5.191

3. Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.

Authors: M Y Khan; R P Gruninger; S M Nelson; R E Klicker
Journal: Antimicrob Agents Chemother Date: 1982-05 Impact factor: 5.191

4. Antibacterial activity of norfloxacin.

Authors: S R Norrby; M Jonsson
Journal: Antimicrob Agents Chemother Date: 1983-01 Impact factor: 5.191

5. In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.

Authors: H C Neu; P Labthavikul
Journal: Antimicrob Agents Chemother Date: 1982-07 Impact factor: 5.191

5 in total

33 in total

1. Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.

Authors: G Garcia-Calvo; A Molleja; M J Giménez; A Parra; E Nieto; C Ponte; L Aguilar; F Soriano
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

2. A norfloxacin dose finding study for selective decontamination of the digestive tract in pigs.

Authors: L A Van der Waaij; O Messerschmidt; D Van der Waaij
Journal: Epidemiol Infect Date: 1989-02 Impact factor: 2.451

3. Hepatobiliary kinetics and excretion of ciprofloxacin.

Authors: M F Parry; D A Smego; M A Digiovanni
Journal: Antimicrob Agents Chemother Date: 1988-07 Impact factor: 5.191

4. Comparison of single-dose treatment with norfloxacin and standard 5-day treatment with trimethoprim-sulfamethoxazole for acute shigellosis in adults.

Authors: E Gotuzzo; R A Oberhelman; C Maguiña; S J Berry; A Yi; M Guzman; R Ruiz; R Leon-Barua; R B Sack
Journal: Antimicrob Agents Chemother Date: 1989-07 Impact factor: 5.191

10. Fosfomycin trometamol in a single dose versus norfloxacin for seven days in the treatment of uncomplicated urinary infections in general practice.

Authors: J B Boerema; F T Willems
Journal: Infection Date: 1990 Impact factor: 3.553

Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.

1. In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.

2. In vitro antibacterial activity of norfloxacin (MK-0366).

3. Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.

4. Antibacterial activity of norfloxacin.

5. In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.

1. Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.

2. A norfloxacin dose finding study for selective decontamination of the digestive tract in pigs.

3. Hepatobiliary kinetics and excretion of ciprofloxacin.

4. Comparison of single-dose treatment with norfloxacin and standard 5-day treatment with trimethoprim-sulfamethoxazole for acute shigellosis in adults.

Review 5. Impact of the fluoroquinolones on gastrointestinal flora.

Review 6. Quinolones in the treatment of acute bacterial diarrhoeal diseases.

Review 7. Use of the quinolones for the prophylaxis and therapy of infections in immunocompromised hosts.

Review 8. Quinolones in Salmonella typhi infection.

Review 9. Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

10. Fosfomycin trometamol in a single dose versus norfloxacin for seven days in the treatment of uncomplicated urinary infections in general practice.