Literature DB >> 6236144

Cytochemical and biochemical studies on neutrophil alkaline phosphatase in parents of trisomy 21 children.

J Grozdea, A Maret, H Vergnes, G Bourrouillou, J Verdier, J Martin, R Salvayre, P Colombies.   

Abstract

A study of karyotypes and neutrophil alkaline phosphatase (NAP) was carried out for 66 parents (33 couples) of trisomy 21 children and for 60 control parents (30 couples). Enzyme activity was determined simultaneously by biochemical and cytochemical techniques. In the mothers of trisomy 21 children we found: (a) by biochemical techniques, a significant increase of NAP activity in polymorphonuclear leukocyte (PMN) homogenates (P less than 0.01) and a lower supernatant/pellet ratio (P less than 0.01); (b) by cytochemical techniques (with or without thermal and urea treatments) NAP activity was significantly higher (P less than 0.001) than in control mothers; in the fathers, the two techniques gave normal NAP activity results.

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Year:  1984        PMID： 6236144     DOI： 10.1007/bf00291360

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  18 in total

1.  Cytochemistry of leukocyte alkaline phosphatase. Use of complex naphthol as phosphates in azo dyecoupling technics.

Authors:  L S KAPLOW
Journal:  Am J Clin Pathol       Date:  1963-05       Impact factor: 2.493

2.  Comparison of human alkaline phosphatase isoenzymes. Structural evidence for three protein classes.

Authors:  M J McKenna; T A Hamilton; H H Sussman
Journal:  Biochem J       Date:  1979-07-01       Impact factor: 3.857

Review 3.  Leukocyte alkaline phosphatase.

Authors:  D B Okun; K R Tanaka
Journal:  Am J Hematol       Date:  1978       Impact factor: 10.047

4.  A rapid banding technique for human chromosomes.

Authors:  M Seabright
Journal:  Lancet       Date:  1971-10-30       Impact factor: 79.321

5.  [Comparison of 2 methods for the determination of leukocyte phosphatase].

Authors:  K Uberla; W Tilling; C Grätzel
Journal:  Blut       Date:  1967-04

6.  Biochemical behavior of intestinal alkaline phosphatase from partially intact preparations.

Authors:  F Pérez-Jiménez; J M Cano; J Muro; G DelaFuente
Journal:  Enzyme       Date:  1983

7.  Rates of chromosome abnormalities at different maternal ages.

Authors:  E B Hook
Journal:  Obstet Gynecol       Date:  1981-09       Impact factor: 7.661

8.  Impairment of polymorphonuclear functions in hospitalized geriatric patients.

Authors:  P Laharrague; J Corberand; G Fillola; F Nguyen; A M Fontanilles; B Gleizes; E Gyrard; C Jean
Journal:  Gerontology       Date:  1983       Impact factor: 5.140

9.  The ultrastructural localization of human neutrophil alkaline phosphatase in normal individuals during pregnancy and in patients with chronic granulocytic leukaemia.

Authors:  P D Wilson; G J Rustin; T J Peters
Journal:  Histochem J       Date:  1981-01

10.  Neutrophil alkaline phosphatase in children with trisomy 21 and their parents.

Authors:  J Grozdea; G Bourrouillou; J Verdier; P Colombies
Journal:  Biomedicine       Date:  1981-09
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  2 in total

1.  Heat resistance, immunological and quantitative changes of neutrophil alkaline phosphatase in trisomy 21 pregnancies.

Authors:  J Grozdea; H Vergnes; A Brisson-Lougarre; G Bourrouillou; J Martin; C Blum; P Colombies
Journal:  Hum Genet       Date:  1988-03       Impact factor: 4.132

2.  Measurement of activity of urea resistant neutrophil alkaline phosphatase as an antenatal screening test for Down's syndrome.

Authors:  H S Cuckle; N J Wald; S F Goodburn; J Sneddon; J A Amess; S C Dunn
Journal:  BMJ       Date:  1990-11-03
  2 in total

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