Literature DB >> 6235466

The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process.

F Moroni, G Lombardi, G Moneti, C Aldinio.   

Abstract

The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

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Year:  1984        PMID： 6235466     DOI： 10.1016/0304-3940(84)90385-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  16 in total

1.  Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.

Authors:  W M H Behan; T W Stone
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

2.  Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate.

Authors:  G Southgate; S Daya
Journal:  Metab Brain Dis       Date:  1999-09       Impact factor: 3.584

3.  Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl.

Authors:  W M Behan; M McDonald; L G Darlington; T W Stone
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

4.  Excitotoxicity of quinolinic acid: modulation by endogenous antagonists.

Authors:  K H Jhamandas; R J Boegman; R J Beninger; A F Miranda; K A Lipic
Journal:  Neurotox Res       Date:  2000       Impact factor: 3.911

5.  An investigation into the neuroprotective properties of ibuprofen.

Authors:  Z Lambat; N Conrad; S Anoopkumar-Dukie; R B Walker; S Daya
Journal:  Metab Brain Dis       Date:  2000-12       Impact factor: 3.584

6.  17Beta-estradiol protects against quinolinic acid-induced lipid peroxidation in the rat brain.

Authors:  P Heron; S Daya
Journal:  Metab Brain Dis       Date:  2000-12       Impact factor: 3.584

7.  Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors.

Authors:  Brian H Harvey; Renché Retief; Ané Korff; Gregers Wegener
Journal:  Metab Brain Dis       Date:  2006-07-22       Impact factor: 3.584

8.  Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity.

Authors:  F Pérez-Severiano; B Escalante; C Ríos
Journal:  Neurochem Res       Date:  1998-10       Impact factor: 3.996

9.  The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression.

Authors:  Marieke C Wichers; Michael Maes
Journal:  J Psychiatry Neurosci       Date:  2004-01       Impact factor: 6.186

10.  Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.

Authors:  Nady Braidy; Bruce J Brew; Nibaldo C Inestrosa; Roger Chung; Perminder Sachdev; Gilles J Guillemin
Journal:  Metab Brain Dis       Date:  2014-05-16       Impact factor: 3.584
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