Literature DB >> 10646692

Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate.

G Southgate1, S Daya.   

Abstract

The protective effects of melatonin against the neurotoxin, quinolinic acid, were investigated in rat brain homogenate using the thiobarbituric acid assay. Quinolinic acid increased lipid peroxidation in a dose dependent manner. When homogenate was cotreated with melatonin there was a significant decrease in lipid peroxidation. The results of the present report show that melatonin may play a protective role in the brain against the neurohormone quinolinic acid, which has been identified as a causative agent in Huntington's Disease.

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Year:  1999        PMID： 10646692     DOI： 10.1023/a:1020610708637

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  21 in total

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Journal:  Adv Pharmacol       Date:  1997

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Journal:  Free Radic Biol Med       Date:  1997       Impact factor: 7.376

5.  Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes.

Authors:  C R Rose; B R Ransom
Journal:  J Neurosci       Date:  1996-09-01       Impact factor: 6.167

6.  Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.

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Journal:  Biochem J       Date:  1996-12-01       Impact factor: 3.857

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Journal:  Eur J Pharmacol       Date:  1996-06-03       Impact factor: 4.432

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Authors:  K A Marshall; R J Reiter; B Poeggeler; O I Aruoma; B Halliwell
Journal:  Free Radic Biol Med       Date:  1996       Impact factor: 7.376

9.  Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

Authors:  R Schwarcz; W O Whetsell; R M Mangano
Journal:  Science       Date:  1983-01-21       Impact factor: 47.728

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Authors:  H Yamamoto; H W Tang
Journal:  Neurosci Lett       Date:  1996-03-29       Impact factor: 3.046
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  9 in total

Review 1.  Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.

Authors:  Seithikurippu R Pandi-Perumal; Ahmed S BaHammam; Gregory M Brown; D Warren Spence; Vijay K Bharti; Charanjit Kaur; Rüdiger Hardeland; Daniel P Cardinali
Journal:  Neurotox Res       Date:  2012-06-28       Impact factor: 3.911

Review 2.  Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology.

Authors:  Neeraj Joshi; Joyshree Biswas; C Nath; Sarika Singh
Journal:  Mol Neurobiol       Date:  2014-08-27       Impact factor: 5.590

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Authors:  H Maharaj; D S Maharaj; S Daya
Journal:  Metab Brain Dis       Date:  2006-07-20       Impact factor: 3.584

4.  An investigation into the neuroprotective properties of ibuprofen.

Authors:  Z Lambat; N Conrad; S Anoopkumar-Dukie; R B Walker; S Daya
Journal:  Metab Brain Dis       Date:  2000-12       Impact factor: 3.584

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Authors:  P Heron; S Daya
Journal:  Metab Brain Dis       Date:  2000-12       Impact factor: 3.584

6.  The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.

Authors:  Xin Wang; Ana Sirianni; Zhijuan Pei; Kerry Cormier; Karen Smith; Jiying Jiang; Shuanhu Zhou; Hui Wang; Rong Zhao; Hiroko Yano; Jeong Eun Kim; Wei Li; Bruce S Kristal; Robert J Ferrante; Robert M Friedlander
Journal:  J Neurosci       Date:  2011-10-12       Impact factor: 6.167

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Authors:  Xin Wang
Journal:  CNS Neurosci Ther       Date:  2009-10-10       Impact factor: 5.243

8.  Antiinflammatory activity of melatonin in central nervous system.

Authors:  Emanuela Esposito; Salvatore Cuzzocrea
Journal:  Curr Neuropharmacol       Date:  2010-09       Impact factor: 7.363

9.  Melatonin in Alzheimer's disease and other neurodegenerative disorders.

Authors:  V Srinivasan; S R Pandi-Perumal; D P Cardinali; B Poeggeler; R Hardeland
Journal:  Behav Brain Funct       Date:  2006-05-04       Impact factor: 3.759
  9 in total

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