Literature DB >> 6233611

Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation.

K A Albert, W C Wu, A C Nairn, P Greengard.   

Abstract

Calmodulin was previously found to inhibit the Ca2+/phospholipid-dependent phosphorylation of an endogenous substrate, called the 87-kilodalton protein, in a crude extract prepared from rat brain synaptosomal cytosol. We investigated the mechanism of this inhibition, using Ca2+/phospholipid-dependent protein kinase and the 87-kilodalton protein, both of which had been purified to homogeneity from bovine brain. Rabbit brain calmodulin and some other Ca2+-binding proteins inhibited the phosphorylation of the 87-kilodalton protein by this kinase in the purified system. Calmodulin also inhibited the Ca2+/phospholipid-dependent phosphorylation of H1 histone, synapsin I, and the delta subunit of the acetylcholine receptor, with use of purified components. These results suggest that calmodulin may be a physiological regulator of Ca2+/phospholipid-dependent protein kinase.

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Year:  1984        PMID： 6233611      PMCID： PMC345270          DOI： 10.1073/pnas.81.12.3622

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  The binding of calmodulin to myelin basic protein and histone H2B.

Authors:  R J Grand; S V Perry
Journal:  Biochem J       Date:  1980-08-01       Impact factor: 3.857

2.  Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.

Authors:  J H Morrissey
Journal:  Anal Biochem       Date:  1981-11-01       Impact factor: 3.365

3.  A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

Authors:  K Sano; Y Takai; J Yamanishi; Y Nishizuka
Journal:  J Biol Chem       Date:  1983-02-10       Impact factor: 5.157

4.  Phosphorylation of calf thymus H1 histone by calcium-activated, phospholipid-dependent protein kinase.

Authors:  Y Iwasa; Y Takai; U Kikkawa; Y Nishizuka
Journal:  Biochem Biophys Res Commun       Date:  1980-09-16       Impact factor: 3.575

5.  Localization of S100 protein in the rat cerebellum: an immunoelectron microscope study.

Authors:  C Legrand; J Clos; J Legrand; O K Langley; M S Ghandour; G Labourdette; G Gombos; G Vincendon
Journal:  Neuropathol Appl Neurobiol       Date:  1981 Jul-Aug       Impact factor: 8.090

6.  Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

Authors:  U Kikkawa; Y Takai; R Minakuchi; S Inohara; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

7.  Modulation of brain protein phosphorylation by the S-100 protein.

Authors:  J Patel; P J Marangos
Journal:  Biochem Biophys Res Commun       Date:  1982-12-31       Impact factor: 3.575

8.  Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.

Authors:  W C Wu; S I Walaas; A C Nairn; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

9.  Inhibition by calmodulin of the cAMP-dependent protein kinase activation of phosphorylase kinase.

Authors:  D E Cox; R D Edstrom
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157

10.  Purification to homogeneity, characterization and monoclonal antibodies of phospholipid-sensitive Ca2+-dependent protein kinase from spleen.

Authors:  R C Schatzman; R L Raynor; R B Fritz; J F Kuo
Journal:  Biochem J       Date:  1983-02-01       Impact factor: 3.857
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  32 in total

1.  The use of dipolar couplings for determining the solution structure of rat apo-S100B(betabeta).

Authors:  A C Drohat; N Tjandra; D M Baldisseri; D J Weber
Journal:  Protein Sci       Date:  1999-04       Impact factor: 6.725

2.  Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

Authors:  J Baudier; C Delphin; D Grunwald; S Khochbin; J J Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

3.  Calcium calmodulin dependent phosphorylation of proteins: fetal cortical neurons and adult cortex.

Authors:  Haviryaji S G Kalluri; Maharaj K Ticku
Journal:  Neurochem Res       Date:  2004-04       Impact factor: 3.996

Review 4.  The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.

Authors:  P J Robinson
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

5.  Inhibition of protein kinase C by calmodulin and calmodulin fragments.

Authors:  H Krüger; K Buchner; W Schröder; H Otto; F Hucho
Journal:  J Protein Chem       Date:  1989-06

Review 6.  The evolution of S100B inhibitors for the treatment of malignant melanoma.

Authors:  Kira G Hartman; Laura E McKnight; Melissa A Liriano; David J Weber
Journal:  Future Med Chem       Date:  2013-01       Impact factor: 3.808

7.  Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

Authors:  M Thelen; M P Wymann; H Langen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

8.  Mechanism of inhibition of protein kinase C by 14-3-3 isoforms. 14-3-3 isoforms do not have phospholipase A2 activity.

Authors:  K Robinson; D Jones; Y Patel; H Martin; J Madrazo; S Martin; S Howell; M Elmore; M J Finnen; A Aitken
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

9.  Acceptors for cyclic AMP-dependent and calcium ion-dependent protein kinases in rat brain cytosol fractions: a comparison of occluded (synaptosomal) cytosol with non-occluded cytosol.

Authors:  R Rodnight; C Perrett; A Dosemeci
Journal:  Neurochem Res       Date:  1986-07       Impact factor: 3.996

10.  Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

Authors:  D J Stumpo; J M Graff; K A Albert; P Greengard; P J Blackshear
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205
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