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Literature DB >> 6957862

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.

W C Wu, S I Walaas, A C Nairn, P Greengard.

Abstract

Depolarization-induced calcium influx into rat cerebral cortex synaptosomes increased the phosphorylation of several synaptosomal proteins as examined by 32Pi incorporation. A phosphopeptide mapping technique involving NaDodSO4/polyacrylamide gels has been used to show that phosphorylation of a Mr 87,000 substrate protein is stimulated by depolarization-induced calcium influx. Phosphorylation of this Mr 87,000 substrate occurred in synaptosomal cytosol and was markedly stimulated by calcium/phosphatidylserine. Calmodulin inhibited this phosphorylation reaction. This substrate for calcium/phospholipid-dependent protein kinase is enriched in and appears to be specific to neurons.

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Year: 1982 PMID： 6957862 PMCID： PMC346873 DOI： 10.1073/pnas.79.17.5249

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

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2. A new spectrophotometric assay for 2',3'-cyclic nucleotide 3'-phosphohydrolase activity in nervous tissue.

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3. Stimulation of synaptic membrane phosphorylation by a calcium and calmodulin independent heat stable cytosol factor.

Authors: J P O'Callaghan; J Juskevich; W Lovenberg
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Authors: J F Kuo; R G Andersson; B C Wise; L Mackerlova; I Salomonsson; N L Brackett; N Katoh; M Shoji; R W Wrenn
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

5. Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex.

Authors: R W Wrenn; N Katoh; B C Wise; J F Kuo
Journal: J Biol Chem Date: 1980-12-25 Impact factor: 5.157

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Authors: W B Huttner; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

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Authors: W B Huttner; L J DeGennaro; P Greengard
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8. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

Authors: A Kishimoto; Y Takai; T Mori; U Kikkawa; Y Nishizuka
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9. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

Authors: Y Takai; A Kishimoto; Y Iwasa; Y Kawahara; T Mori; Y Nishizuka
Journal: J Biol Chem Date: 1979-05-25 Impact factor: 5.157

10. Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture.

Authors: L K Kaczmarek; K R Jennings; F Strumwasser; A C Nairn; U Walter; F D Wilson; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

56 in total

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6. Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

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8. Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.

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Authors: R Rodnight; C Perrett; A Dosemeci
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10. Protein kinase Cepsilon is important for migration of neuroblastoma cells.

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