Literature DB >> 2580482

Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.

D F Smee, S S Knight, A E Duke, W S Robinson, T R Matthews, P L Marion.   

Abstract

Treatment of chronic ground squirrel hepatitis virus infection with arabinosyladenine monophosphate at 20 mg/kg per day for 3 weeks caused marked decreases in serum virion-associated DNA polymerase concentrations in three of five squirrels. Statistically significant but less dramatic decreases in enzymatic activity were noted in two of six squirrels treated with 50 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine per kg per day. After therapy, DNA polymerase activities rose to pretreatment levels.

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Year:  1985        PMID： 2580482      PMCID： PMC176255          DOI： 10.1128/AAC.27.2.277

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

Authors:  J Summers; J M Smolec; R Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Antiviral treatment of chronic hepatitis B virus infection: improvement in liver disease with interferon and adenine arabinoside.

Authors:  G H Scullard; L L Andres; H B Greenberg; J L Smith; V K Sawhney; E A Neal; A S Mahal; H Popper; T C Merigan; W S Robinson; P B Gregory
Journal:  Hepatology       Date:  1981 May-Jun       Impact factor: 17.425

3.  Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.

Authors:  W S Mason; G Seal; J Summers
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

4.  Successful treatment of HBs and HBeAg positive chronic liver disease: prolonged inhibition of viral replication by highly soluble adenine arabinoside 5'-monophosphate (ARA-AMP).

Authors:  I V Weller; M F Bassendine; A Craxi; M J Fowler; J Monjardino; H C Thomas; S Sherlock
Journal:  Gut       Date:  1982-09       Impact factor: 23.059

5.  State of hepatitis B viral DNA in a human hepatoma cell line.

Authors:  P L Marion; F H Salazar; J J Alexander; W S Robinson
Journal:  J Virol       Date:  1980-02       Impact factor: 5.103

6.  Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside.

Authors:  G H Scullard; R B Pollard; J L Smith; S L Sacks; P B Gregory; W S Robinson; T C Merigan
Journal:  J Infect Dis       Date:  1981-06       Impact factor: 5.226

7.  Antiviral treatment of chronic hepatitis B virus infection: pharmacokinetics and side effects of interferon and adenine arabinoside alone and in combination.

Authors:  S L Sacks; G H Scullard; R B Pollard; P B Gregory; W S Robinson; T C Merigan
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

8.  Antiviral treatment of chronic hepatitis B virus infection: infectious virus cannot be detected in patient serum after permanent responses to treatment.

Authors:  G H Scullard; H B Greenberg; J L Smith; P B Gregory; T C Merigan; W S Robinson
Journal:  Hepatology       Date:  1982 Jan-Feb       Impact factor: 17.425

9.  A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

Authors:  P L Marion; L S Oshiro; D C Regnery; G H Scullard; W S Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

10.  Ground squirrel hepatitis virus DNA: molecular cloning and comparison with hepatitis B virus DNA.

Authors:  A Siddiqui; P L Marion; W S Robinson
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103
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  5 in total

Review 1.  Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections.

Authors:  D Faulds; R C Heel
Journal:  Drugs       Date:  1990-04       Impact factor: 9.546

2.  In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.

Authors:  J M Cullen; S L Smith; M G Davis; S E Dunn; C Botteron; A Cecchi; D Linsey; D Linzey; L Frick; M T Paff; A Goulding; K Biron
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

3.  In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus.

Authors:  T Shaw; P Amor; G Civitico; M Boyd; S Locarnini
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

4.  The carbocyclic analog of 2'-deoxyguanosine induces a prolonged inhibition of duck hepatitis B virus DNA synthesis in primary hepatocyte cultures and in the liver.

Authors:  I Fourel; J Saputelli; P Schaffer; W S Mason
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103

5.  Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model.

Authors:  L D Condreay; R W Jansen; T F Powdrill; L C Johnson; D W Selleseth; M T Paff; S M Daluge; G R Painter; P A Furman; M N Ellis
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191
  5 in total

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