Role of platelet antagonists in coronary artery disease: implications in coronary artery bypass surgery and balloon-catheter dilatation.

Platelets play an important role in regulation of hemostasis and maintenance of vascular tone. Endothelial disruption occurring during coronary artery bypass surgery and balloon-catheter dilatation may promote platelet adhesion, aggregation, and thrombus formation. Recent studies suggest that platelet-endothelial interaction is mediated in part through products of arachidonic acid metabolism. Understanding of the platelet interaction with blood vessels is important in pharmacologic interventions directed at prevention of thrombus formation in bypass grafts. Although it remains to be proved, use of platelet-suppressive drugs may also improve patency of coronary arteries after balloon-catheter dilatation.