Literature DB >> 6228217

Successful treatment of acute dapsone intoxication using charcoal hemoperfusion.

Z H Endre, J A Charlesworth, G J Macdonald, L Woodbridge.   

Abstract

A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone. Over the next 15 h she developed progressive hemolysis and methemoglobinemia. Charcoal hemoperfusion and sequential dialysis were performed because of the serious risk of fatality following such a massive dose of dapsone. Charcoal hemoperfusion led to rapid clearing of dapsone from the circulation. This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.

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Year:  1983        PMID: 6228217     DOI: 10.1111/j.1445-5994.1983.tb02704.x

Source DB:  PubMed          Journal:  Aust N Z J Med        ISSN: 0004-8291


  5 in total

1.  Management of dapsone poisoning complicated by methaemoglobinaemia.

Authors:  A H Dawson; I M Whyte
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Sep-Oct

2.  Acute dapsone poisoning in a 3-year-old child: Case report with review of literature.

Authors:  Menon Narayanankutty Sunilkumar; Thekkuttuparambil Ananthanarayanan Ajith; Vadakut Krishnan Parvathy
Journal:  World J Clin Cases       Date:  2015-10-16       Impact factor: 1.337

Review 3.  Clinical pharmacokinetics of dapsone.

Authors:  J Zuidema; E S Hilbers-Modderman; F W Merkus
Journal:  Clin Pharmacokinet       Date:  1986 Jul-Aug       Impact factor: 6.447

Review 4.  Clinical features and management of poisoning due to antimalarial drugs.

Authors:  A Jaeger; P Sauder; J Kopferschmitt; F Flesch
Journal:  Med Toxicol Adverse Drug Exp       Date:  1987 Jul-Aug

5.  Dapsone-induced Methemoglobinemia in a Child with End-stage Renal Disease: A Brief Review.

Authors:  Madhuradhar Chegondi; Irina Ten; Balagangadhar Totapally
Journal:  Cureus       Date:  2018-04-20
  5 in total

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