Literature DB >> 6227513

Regulation of mucosal phosphofructokinase in the small intestine of the streptozotocin-diabetic rat.

A Jamal, G L Kellett.   

Abstract

The total activity of mucosal phosphofructokinase in the proximal jejunum of the streptozotocin-diabetic at was found to be diminished compared with normal from 13.4 to 10.4 units/g wet weight, mucosa and the activity ratio of the enzyme at pH 7 was diminished from 0.40 to 0.23, indicating that the enzyme is more susceptible to inhibition by ATP. The combination of these changes is, in principle, more than sufficient to account for the 29% decrease in glucose utilisation observed in the jejunum of diabetic rats. Insulin, when injected in vivo, has the ability to restore both the total activity and the regulatory properties of phosphofructokinase to normal in streptozotocin-diabetic rats. The action of insulin is blocked by the protein synthesis inhibitor cycloheximide, and is not mediated by changes in blood glucose levels.

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Year:  1983        PMID： 6227513     DOI： 10.1007/bf00253201

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  21 in total

1.  Glucose metabolism in jejunal mucosa of fed, fasted, and streptozotocin-diabetic rats.

Authors:  J W Anderson
Journal:  Am J Physiol       Date:  1974-01

Review 2.  Effect of insulin and experimental diabetes mellitus on the digestive-absorptive function of the small intestine.

Authors:  W F Caspary
Journal:  Digestion       Date:  1973-10       Impact factor: 3.216

3.  Phosphate content of muscle phosphofructokinase in the genetically diabetic mouse (C57BL/KsJ).

Authors:  S E Bazaes; L G Foe; R G Kemp
Journal:  Arch Biochem Biophys       Date:  1982-10-15       Impact factor: 4.013

4.  Evidence for the presence of insulin binding sites in isolated rat intestinal epithelial cells.

Authors:  M E Forgue-Lafitte; M R Marescot; M C Chamblier; G Rosselin
Journal:  Diabetologia       Date:  1980-10       Impact factor: 10.122

5.  Dietary regulation of fructose metabolism in the intestine and in the liver of the rat: time response and effect of cycloheximide.

Authors:  G Crouzoulon; G Dandrifosse
Journal:  Int J Biochem       Date:  1979

6.  The tissue distribution of fructose-2,6-p2 and fructose-6-P,2-kinase in rats and the effect of starvation diabetes and hypoglycemia on hepatic fructose-2,6-P2 and fructose-6-P,2-kinase.

Authors:  M Kuwajima; K Uyeda
Journal:  Biochem Biophys Res Commun       Date:  1982-01-15       Impact factor: 3.575

7.  The isolation and characterization of differentially phosphorylated fractions of phosphofructokinase from rabbit skeletal muscle.

Authors:  C R Hussey; P F Liddle; D Ardron; G L Kellett
Journal:  Eur J Biochem       Date:  1977-11-01

8.  Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

Authors:  E Van Schaftingen; L Hue; H G Hers
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

9.  Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase.

Authors:  E Van Schaftingen; L Hue; H G Hers
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

10.  Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate.

Authors:  P Neely; M R El-Maghrabi; S J Pilkis; T H Claus
Journal:  Diabetes       Date:  1981-12       Impact factor: 9.461
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  12 in total

1.  In vitro study on the contribution of the rat intestine-pancreas to glucose homeostasis.

Authors:  M A Tormo; M A Zubeldia; J L Montero; J E Campillo
Journal:  Diabetologia       Date:  1988-12       Impact factor: 10.122

2.  Rapid regulation of rat jejunal glucose transport by insulin in a luminally and vascularly perfused preparation.

Authors:  A M Pennington; C P Corpe; G L Kellett
Journal:  J Physiol       Date:  1994-07-15       Impact factor: 5.182

3.  Fructose 2,6-bisphosphate in isolated rat enterocytes.

Authors:  J Louis; B Philippe; L Hue
Journal:  Biochem J       Date:  1985-12-01       Impact factor: 3.857

4.  Regulation of glucose homeostasis in rat jejunum by despentapeptide-insulin in vitro.

Authors:  N Wollen; G L Kellett
Journal:  Gut       Date:  1988-08       Impact factor: 23.059

5.  Short-term regulation of glycolysis by vasoactive intestinal peptide in epithelial cells isolated from rat small intestine.

Authors:  I Rossi; L Monge; J E Feliu
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

6.  The acute regulation of glucose absorption, transport and metabolism in rat small intestine by insulin in vivo.

Authors:  G L Kellett; A Jamal; J P Robertson; N Wollen
Journal:  Biochem J       Date:  1984-05-01       Impact factor: 3.857

7.  A protein inhibitor of phosphofructokinase from the mucosa of rat small intestine. A mechanism for the regulation of glycolysis that is independent of glucose.

Authors:  G L Kellett; J P Robertson
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

8.  The effect of glucose on the activity of phosphofructokinase in the mucosa of rat small intestine.

Authors:  A Jamal; G L Kellett; J P Robertson
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857

9.  Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro.

Authors:  M A Tormo; M A Gómez-Zubeldia; F Ropero; M Muñoz-Casillas; J C Moreno; J E Campillo
Journal:  Acta Diabetol       Date:  1995-10       Impact factor: 4.280

10.  Effect of insulin and gliclazide on glucose utilization by a perfused intestine-pancreas preparation isolated from diabetic and non-diabetic rats.

Authors:  M A Tormo; M A Gomez-Zubeldia; F Ropero; J E Campillo
Journal:  Acta Diabetol       Date:  1994-09       Impact factor: 4.280
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