Literature DB >> 6225430

Metabolism of ethylmalonate to mesaconate in the rat. Evidence for trans-dehydrogenation of methylsuccinate.

J A Montgomery, O A Mamer, C R Scriver.   

Abstract

Rats excrete increased ethylmalonate and methylsuccinate when given ethylmalonate in the diet; when given methylsuccinate they excrete methylsuccinate and mesaconate. Tenfold more labelled mesaconate was produced from threo-methyl[2,3-2H2] succinate precursor than from the erythro isomer. Our findings suggest trans-dehydrogenation of methylsuccinate and are the first direct evidence linking the metabolism of ethylmalonate, methylsuccinate and mesaconate.

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Year:  1983        PMID： 6225430      PMCID： PMC1152292          DOI： 10.1042/bj2140641

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  Mechanism of the succinic dehydrogenase catalysed reaction.

Authors:  O GAWRON; A J GLAID; J FRANCISCO; T P FONDY
Journal:  Nature       Date:  1963-03-30       Impact factor: 49.962

2.  Investigation of the mechanism of the methylmalonyl-CoA mutase reaction with the substrate analogue: ethylmalonyl-CoA.

Authors:  J Rétey; E H Smith; B Zagalak
Journal:  Eur J Biochem       Date:  1978-02

3.  Isolation and identification of methylcitrate, a major metabolic product of propionate in patients with propionic acidemia.

Authors:  T Ando; K Rasmussen; J M Wright; W L Nyhan
Journal:  J Biol Chem       Date:  1972-04-10       Impact factor: 5.157

4.  A rapid method for the analysis of urinary methylmalonic acid.

Authors:  B F Gibbs; K Itiaba; O A Mammer; J C Crawhall; B A Cooper
Journal:  Clin Chim Acta       Date:  1972-05       Impact factor: 3.786

5.  Demonstration of a new mammalian isoleucine catabolic pathway yielding an Rseries of metabolites.

Authors:  O A Mamer; S S Tjoa; C R Scriver; G A Klassen
Journal:  Biochem J       Date:  1976-12-15       Impact factor: 3.857

6.  Microdetermination of methylmalonic acid and other short chain dicarboxylic acids by gas chromatography: use in prenatal diagnosis of methylmalonic acidemia and in studies of isovaleric acidemia.

Authors:  E Nakamura; L E Rosenberg; K Tanaka
Journal:  Clin Chim Acta       Date:  1976-04-15       Impact factor: 3.786

7.  New metabolites in isovaleric acidemia.

Authors:  R J Truscott; D Malegan; E McCairns; D Burke; L Hick; P Sims; B Halpern; K Tanaka; L Sweetman; W L Nyhan; J Hammond; C Bumack; E A Haan; D M Danks
Journal:  Clin Chim Acta       Date:  1981-03-05       Impact factor: 3.786
  7 in total
  3 in total

Review 1.  Metabolite proofreading, a neglected aspect of intermediary metabolism.

Authors:  Emile Van Schaftingen; Rim Rzem; Alexandre Marbaix; François Collard; Maria Veiga-da-Cunha; Carole L Linster
Journal:  J Inherit Metab Dis       Date:  2013-01-08       Impact factor: 4.982

2.  The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.

Authors:  Hongying Shen; Gregory C Campanello; Daniel Flicker; Zenon Grabarek; Junchi Hu; Cheng Luo; Ruma Banerjee; Vamsi K Mootha
Journal:  Cell       Date:  2017-10-19       Impact factor: 41.582

3.  Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate.

Authors:  Moritz Winterhoff; Fangfang Chen; Nishika Sahini; Thomas Ebensen; Maike Kuhn; Volkhard Kaever; Heike Bähre; Frank Pessler
Journal:  Metabolites       Date:  2021-04-26
  3 in total

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