Literature DB >> 6222048

Calcium inhibition of rat liver microsomal calcium-dependent ATPase.

W J Brattin, R L Waller.   

Abstract

Measurement of the inward rate of Ca2+ transport by rat liver microsomes under conditions of varying free intravesicular Ca2+ (1 microM to 5 mM) revealed that inward transport rate is maximum at low intravesicular Ca2+, and that transport rate decreases with an apparent inhibition constant of about 250-350 microM as intravesicular Ca2+ accumulates. This relationship is confirmed by measurement of Ca2+-dependent ATPase activity; activity is greatest when intravesicular Ca2+ is 1 microM, is lower when intravesicular Ca2+ is 60 microM, and is minimum when intravesicular Ca2+ is 5 mM. Unexpectedly, the ratio of Ca2+ transport rate to Ca2+-dependent ATP hydrolysis rate appears to be significantly greater than 2:1.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6222048

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  6 in total

1.  A continuous fluorimetric assay for ATPase activity.

Authors:  U Banik; S Roy
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

2.  Further characterization of the plasma membrane- and intracellular membrane-associated platelet Ca2+ transport systems.

Authors:  J Enouf; R Bredoux; N Bourdeau; B Sarkadi; S Levy-Toledano
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

3.  Physiological concentrations of inorganic phosphate affect MgATP-dependent Ca2+ storage and inositol trisphosphate-induced Ca2+ efflux in microsomal vesicles from non-hepatic cells.

Authors:  R Fulceri; G Bellomo; A Gamberucci; A Romani; A Benedetti
Journal:  Biochem J       Date:  1993-01-01       Impact factor: 3.857

4.  Long-term potentiation of transmitter release induced by repetitive presynaptic activities in bull-frog sympathetic ganglia.

Authors:  K Koyano; K Kuba; S Minota
Journal:  J Physiol       Date:  1985-02       Impact factor: 5.182

5.  A steady-state mechanism can account for the properties of inositol 2,4,5-trisphosphate-stimulated Ca2+ release from permeabilized L1210 cells.

Authors:  J W Loomis-Husselbee; A P Dawson
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857

Review 6.  Signal transduction mechanisms involved in hormonal Ca2+ fluxes.

Authors:  J R Williamson; J R Monck
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.