Literature DB >> 6218302

Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.

G C Rovnyak, R C Millonig, J Schwartz, V Shu.   

Abstract

A series of novel hexahydrothiopyrano[4,3-c]pyrazoles and related analogues were prepared and tested for antiinflammatory activity by using the mouse active Arthus reaction and the delayed hypersensitivity skin reaction in guinea pigs as primary screens. The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis; in this system, both compounds were active when dosed intraperitoneally but failed to produce significant activity when dosed orally at subtoxic doses.

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Year:  1982        PMID： 6218302     DOI： 10.1021/jm00354a018

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic α-Quaternary Ketones.

Authors:  Eric J Alexy; Scott C Virgil; Michael D Bartberger; Brian M Stoltz
Journal:  Org Lett       Date:  2017-09-13       Impact factor: 6.005

2.  Ethyl 2-(6-amino-5-cyano-3,4-dimethyl-2H,4H-pyrano[2,3-c]pyrazol-4-yl)acetate.

Authors:  M Kannan; Kandhasamy Kumaravel; Gnanasambandam Vasuki; R Krishna
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-30

3.  From small structural modifications to adjustment of structurally dependent properties: 1-methyl-3,5-bis[(E)-2-thienylidene]-4-piperidone and 3,5-bis[(E)-5-bromo-2-thienylidene]-1-methyl-4-piperidone.

Authors:  Paul Tongwa; Tiffany L Kinnibrugh; Geetha R Kicchaiahgari; Victor N Khrustalev; Tatiana V Timofeeva
Journal:  Acta Crystallogr C       Date:  2009-03-18       Impact factor: 1.172

4.  (E)-3-(4-Chloro-phen-yl)-3-[3-(4-chloro-phen-yl)-1H-pyrazol-1-yl]prop-2-enal.

Authors:  V Susindran; S Athimoolam; S Asath Bahadur; R Manikannan; S Muthusubramanian
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-18

5.  Synthesis and Antimicrobial Activity of Some New 2-(3-(4-Aryl)-1-phenyl-1H-pyrazol-4-yl) Chroman-4-ones.

Authors:  O Prakash; K Hussain; K R Aneja; C Sharma
Journal:  Indian J Pharm Sci       Date:  2011-09       Impact factor: 0.975
  5 in total

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