Literature DB >> 6215195

An increase in peripheral blood Ia-positive T cells in Sjögren's syndrome correlates with a decrease in the autologous mixed lymphocyte response.

B Sauvezie, N Miyasaka, D Charron, C Kielich, J Loeb, T E Daniels, N Talal.   

Abstract

The defective autologous MLR was studied in Sjögren's syndrome (SS) in relation to Ia+ cells as determined by reactivity with a monoclonal anti-human Ia antibody. By indirect immunofluorescence, the percentage of Ia+ T lymphocytes was increased in nine of 15 patients. There was no correlation with clinical features or drugs. The percentage of Ia+ T cells in the non-T cell preparations was normal. An inverse correlation was found between the percentage of Ia+ T cells and the proliferative response to autologous non-T cells. Removal of Ia+ T cells enhanced both the autologous MLR and the allogeneic MLR. Thus Ia+ T cells contain suppressor cells in the MLR, but this may not be the sole explanation for the defective autologous MLR.

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Year:  1982        PMID： 6215195      PMCID： PMC1536652     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  30 in total

1.  The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus.

Authors:  M M Kuntz; J B Innes; M E Weksler
Journal:  J Clin Invest       Date:  1979-01       Impact factor: 14.808

2.  The oral component of Sjögren's syndrome.

Authors:  T E Daniels; S Silverman; J P Michalski; J S Greenspan; R A Sylvester; N Talal
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1975-06

Review 3.  Expression of Ia antigens on T and B cells and their relationship to immune-response functions.

Authors:  J E Niederhuber; J A Frelinger
Journal:  Transplant Rev       Date:  1976

4.  Aberrations of suppressor T cells in human graft-versus-host disease.

Authors:  E L Reinherz; R Parkman; J Rappeport; F S Rosen; S F Schlossman
Journal:  N Engl J Med       Date:  1979-05-10       Impact factor: 91.245

5.  Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus.

Authors:  T Sakane; A D Steinberg; I Green
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

6.  Immunologic studies in chronic lymphocytic leukemia: defective stimulation of T-cell proliferation in autologous mixed lymphocyte culture.

Authors:  J B Smith; R P Knowlton; L S Koons
Journal:  J Natl Cancer Inst       Date:  1977-03       Impact factor: 13.506

7.  Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity.

Authors:  S M Fu; N Chiorazzi; C Y Wang; G Montrazeri; H G Kunkel; H S Ko; A B Gottlieb
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

8.  Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.

Authors:  R L Evans; T J Faldetta; R E Humphreys; D M Pratt; E J Yunis; S F Schlossman
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

9.  Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.

Authors:  D H Katz; M Graves; M E Dorf; H Dimuzio; B Benacerraf
Journal:  J Exp Med       Date:  1975-01-01       Impact factor: 14.307

10.  Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes.

Authors:  R J Winchester; P Wernet; H G Kunkel; B Dupont; C Jersild; S M Fu
Journal:  J Exp Med       Date:  1975-04-01       Impact factor: 14.307
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  9 in total

1.  Studies of proliferative responses by long-term-cryopreserved peripheral blood mononuclear cells to bacterial components associated with periodontitis.

Authors:  G A Miller; M F Hickey; M M D'Alesandro; B K Nicoll
Journal:  Clin Diagn Lab Immunol       Date:  1996-11

2.  Increased circulating Ia-positive T cells in patients with idiopathic thrombocytopenic purpura.

Authors:  H Mizutani; T Tsubakio; Y Tomiyama; S Katagiri; T Tamaki; Y Kurata; T Yonezawa; S Tarui
Journal:  Clin Exp Immunol       Date:  1987-01       Impact factor: 4.330

3.  Activation of peripheral blood lymphocytes in patients with primary Sjögren's syndrome.

Authors:  P Youinou; Y L Pennec; M A Blaschek; A Gentric; J Jouquan; A Lamour; P Angelidis
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

4.  Increased Ia expression, T lymphocyte subset abnormalities and autoimmunity in murine strains bearing the lpr gene.

Authors:  M J Dauphinée; N Talal
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

5.  Increased peripheral blood Ia positive T cells and their effect on autologous mixed lymphocyte reaction in chronic active liver disease.

Authors:  K Fukui; S Kakumu; H Murakami; J Kuriki; K Yoshioka; N Sakamoto
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

6.  Correlation of disease activity and drug therapy with the autologous mixed lymphocyte reaction in rheumatoid arthritis.

Authors:  S M Cross; R A Hazelton
Journal:  Ann Rheum Dis       Date:  1985-04       Impact factor: 19.103

7.  The distribution and functional properties of dendritic cells in patients with seronegative arthritis.

Authors:  A J Stagg; B Harding; R A Hughes; A Keat; S C Knight
Journal:  Clin Exp Immunol       Date:  1991-04       Impact factor: 4.330

8.  Analysis of the responding and stimulating cells in the AMLR of patients with rheumatoid arthritis using limiting dilution.

Authors:  R A Hazelton; J J Morrison; R Vedam; V Siskind
Journal:  Clin Exp Immunol       Date:  1988-10       Impact factor: 4.330

9.  Impaired autologous mixed-lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis.

Authors:  S Kimura; N Fujimoto; H Okada
Journal:  Infect Immun       Date:  1991-12       Impact factor: 3.441
  9 in total

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