Literature DB >> 153913

The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus.

M M Kuntz, J B Innes, M E Weksler.   

Abstract

The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.

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Year:  1979        PMID： 153913      PMCID： PMC371930          DOI： 10.1172/JCI109270

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  9 in total

1.  SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE.

Authors:  L S KAPLOW
Journal:  Blood       Date:  1965-08       Impact factor: 22.113

2.  Responses of fractionated cells from patients with systemic lupus erythematosus and normals to plant mitogen: evidence for a suppressor population of monocytes.

Authors:  J A Markenson; J W Morgan; M D Lockshin; C Joachim; J B Winfield
Journal:  Proc Soc Exp Biol Med       Date:  1978-05

3.  Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus.

Authors:  B Bresnihan; H E Jasin
Journal:  J Clin Invest       Date:  1977-01       Impact factor: 14.808

4.  Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus.

Authors:  T Sakane; A D Steinberg; I Green
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

5.  Loss of suppressor T cells in adult NZB/NZW mice.

Authors:  R S Krakauer; T A Waldmann; W Strober
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307

6.  Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction.

Authors:  M E Weksler; R Kozak
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

7.  Autologous stimulation of human lymphocyte subpopulation.

Authors:  G Opelz; M Kiuchi; M Takasugi; P I Terasaki
Journal:  J Exp Med       Date:  1975-11-01       Impact factor: 14.307

8.  Autologous mixed lymphocyte culture reactions and generation of cytotoxic T cells.

Authors:  R A Vande Stouwe; H G Kunkel; J P Halper; M E Weksler
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

9.  Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.

Authors:  M M Kuntz; J B Innes; M E Weksler
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307
  9 in total
  33 in total

1.  Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.

Authors:  J B Innes; M M Kuntz; Y T Kim; M E Weksler
Journal:  J Clin Invest       Date:  1979-12       Impact factor: 14.808

2.  Immunoglobulin production in the autologous MLR: target of the suppressor-amplifier circuit.

Authors:  P A Gatenby; E G Engleman
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

3.  Activation of immune regulatory circuits among OKT4+ cells by autologous mixed lymphocyte reactions.

Authors:  H Kotani; S Takada; Y Ueda; Y Murakawa; N Suzuki; T Sakane
Journal:  Clin Exp Immunol       Date:  1984-05       Impact factor: 4.330

4.  Phorbol ester treated chronic B lymphocytic leukaemia cells induce autologous T cell proliferation without generation of cytotoxic T cells.

Authors:  D Kabelitz; T H Tötterman; K Nilsson; M Gidlund
Journal:  Clin Exp Immunol       Date:  1984-08       Impact factor: 4.330

5.  Frequency in human peripheral blood of T cells which respond to self, modified self and alloantigens.

Authors:  J B Smith
Journal:  Immunology       Date:  1983-10       Impact factor: 7.397

6.  Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

Authors:  L Fuller; C Flaa; D Jaffe; J Strauss; G K Kyriakides; J Miller
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

7.  Studies on the syngeneic mixed lymphocyte reaction. II. Decline in he syngeneic mixed lymphocyte reaction with age.

Authors:  J K Gutowski; M E Weksler
Journal:  Immunology       Date:  1982-08       Impact factor: 7.397

8.  Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus.

Authors:  Charles S Via; Gene M Shearer
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

9.  Differences in the kinetics of the autologous mixed lymphocyte reaction between the various connective tissue diseases.

Authors:  A Laffón; J Alcocer-Varela; D Alarcón-Segovia
Journal:  Rheumatol Int       Date:  1983       Impact factor: 2.631

10.  Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

Authors:  J Alcocer-Varela; D Alarcón-Segovia
Journal:  J Clin Invest       Date:  1982-06       Impact factor: 14.808
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