[Humoral immune response, concentration of selected serum proteins and transplant histology following allogeneic kidney transplantation in the rat].

After transplantation of (BD IX X Sprague-Dawley) F 1 kidneys into untreated BD IX rats (n = 29) the first signs of rejection occured on day 4. Mononuclear cells infiltrated the peritubular interstitium and/or the perivascular areas. The rise of blood urea on day 8 was histologically accompanied by injured tubules and spotted or confluent subcapsular necroses which showed extensive calcifications by day 10. At the same time donorspecific lymphocytotoxic antibodies were detected in peripheral blood. The graft survival in this strain combination ranged from 11 to 16 days. The serum levels of IgG, albumin and transferrin were reduced by 16%, 25% and 21% resp. in the 1st posttransplant week. In contrast, the serum level of alpha 2-macroglobulin rose on the 2nd postoperative day to an average of 800% above the mean. In connection with rejections only the alpha 2-macroglobulin showed changes of the serum level.