Literature DB >> 6208381

Identification and characterization of a cellular protein that cross-reacts with the Epstein-Barr virus nuclear antigen.

J Luka, T Kreofsky, G R Pearson, K Hennessy, E Kieff.   

Abstract

A 62,000-dalton (62K) cell protein reacts with antisera to the 72K polypeptide of the Epstein-Barr virus nuclear antigen (EBNA) in immunoblots. This protein was initially detected in EBNA-negative as well as EBNA-positive cell lines with anti-EBNA-positive human sera. A monoclonal antibody raised against the 72K EBNA and an antiserum from a rabbit immunized with the glycine-alanine domain of EBNA also reacted with the cellular protein. The cellular protein was partially purified from Epstein-Barr virus genome-positive and -negative cell lines. Absorption experiments identified a shared antigenic determinant between the 72K EBNA and 62K cellular protein. A comparison of the 62K protein and EBNA by protease digestion did not reveal similar peptides.

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Year:  1984        PMID： 6208381      PMCID： PMC254603     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

2.  Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors:  B M Reedman; G Klein
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Evidence for two classes of chromatin-associated Epstein-Barr virus-determined nuclear antigen.

Authors:  T C Spelsberg; T B Sculley; G M Pikler; J A Gilbert; G R Pearson
Journal:  J Virol       Date:  1982-08       Impact factor: 5.103

5.  Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections.

Authors:  M Heller; V van Santen; E Kieff
Journal:  J Virol       Date:  1982-10       Impact factor: 5.103

6.  Partial purification of the Epstein-Barr virus nuclear antigen(s).

Authors:  T B Sculley; T Kreofsky; G R Pearson; T C Spelsberg
Journal:  J Biol Chem       Date:  1983-03-25       Impact factor: 5.157

Review 7.  Theory and methods for immunization in culture and monoclonal antibody production.

Authors:  C L Reading
Journal:  J Immunol Methods       Date:  1982-09-30       Impact factor: 2.303

8.  Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis.

Authors:  B C Strnad; T C Schuster; R F Hopkins; R H Neubauer; H Rabin
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

9.  Identification of Epstein-Barr virus strain differences with monoclonal antibody to a membrane glycoprotein.

Authors:  L F Qualtiere; R Chase; B Vroman; G R Pearson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

10.  Studies on Epstein-Barr virus-related antigens. III. Purification of the virus-determined nuclear antigen (EBNA) from non-producer Raji cells.

Authors:  T Matsuo; N Hibi; S Nishi; H Hirai; T Osato
Journal:  Int J Cancer       Date:  1978-12       Impact factor: 7.396
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  21 in total

1.  Epstein-Barr virus nuclear antigen 1 linear epitopes that are reactive with immunoglobulin A (IgA) or IgG in sera from nasopharyngeal carcinoma patients or from healthy donors.

Authors:  H M Cheng; Y T Foong; C K Sam; U Prasad; J Dillner
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

2.  Antigenic mimicry of a human cellular polypeptide by Mycoplasma hyorhinis.

Authors:  P D Fernsten; K W Pekny; J R Harper; L E Walker
Journal:  Infect Immun       Date:  1987-07       Impact factor: 3.441

3.  Characterization of the restricted component of Epstein-Barr virus early antigens as a cytoplasmic filamentous protein.

Authors:  J Luka; G Miller; H Jörnvall; G R Pearson
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

4.  Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1.

Authors:  J H Vaughan; J R Valbracht; M D Nguyen; H H Handley; R S Smith; K Patrick; G H Rhodes
Journal:  J Clin Invest       Date:  1995-03       Impact factor: 14.808

5.  Induction of anti-EBNA-1 protein by 12-O-tetradecanoylphorbol-13-acetate treatment of human lymphoblastoid cells.

Authors:  L T Wen; A Tanaka; M Nonoyama
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

6.  A model for the development of the tandem repeat units in the EBV ori-P region and a discussion of their possible function.

Authors:  S Karlin; B E Blaisdell
Journal:  J Mol Evol       Date:  1987       Impact factor: 2.395

7.  Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat.

Authors:  M Heller; E Flemington; E Kieff; P Deininger
Journal:  Mol Cell Biol       Date:  1985-03       Impact factor: 4.272

8.  2.2-kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169.

Authors:  S I Staprans; D H Spector
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

9.  Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen.

Authors:  R Fox; R Sportsman; G Rhodes; J Luka; G Pearson; J Vaughan
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

Review 10.  Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.

Authors:  M A Nalesnik; T E Starzl
Journal:  Transplant Sci       Date:  1994-09
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