| Literature DB >> 6206398 |
E Westhof, D Altschuh, D Moras, A C Bloomer, A Mondragon, A Klug, M H Van Regenmortel.
Abstract
Most continuous antigenic determinants of tobacco mosaic virus protein (TMVP), myoglobin and lysozyme correspond to those surface regions in the protein structure, as determined by X-ray crystallography, which possess a run of high-temperature factors along the polypeptide backbone, that is, a high segmental mobility. The mobility of an antigenic determinant may make it easier to adjust to a pre-existing antibody site not fashioned to fit the exact geometry of a protein. The correlation found between temperature factors and antigenicity is better than that between hydrophilicity and antigenicity.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6206398 DOI： 10.1038/311123a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962