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Literature DB >> 6206100

Monoclonal antibody to cytokeratin for use in routine histopathology.

Abstract

CAM 5.2 is a murine monoclonal antibody, raised against the colon carcinoma cell line HT29, which recognises lower molecular weight intracellular cytokeratin proteins within secretory epithelia. Extensive indirect immunohistochemical studies have confirmed that this antibody stains formalin fixed (and freshly frozen) normal and malignant human tissue in a consistent manner. Reliable staining of conventionally processed pathological tissues provides more accurate identification and staging of human malignant epithelial diseases.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6206100 PMCID： PMC498911 DOI： 10.1136/jcp.37.9.975

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

21 in total

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

2. A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.

Authors: E Heyderman; K Steele; M G Ormerod
Journal: J Clin Pathol Date: 1979-01 Impact factor: 3.411

3. The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique.

Authors: B L Mepham; W Frater; B S Mitchell
Journal: Histochem J Date: 1979-05

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

5. Expression of endodermally derived and neural crest-derived differentiation antigens by human lung and colon tumors.

Authors: C E Bell; S Seetharam
Journal: Cancer Date: 1979-07 Impact factor: 6.860

6. Classification of human colorectal adenocarcinoma cell lines.

Authors: A Leibovitz; J C Stinson; W B McCombs; C E McCoy; K C Mazur; N D Mabry
Journal: Cancer Res Date: 1976-12 Impact factor: 12.701

7. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.

Authors: C J Barnstable; W F Bodmer; G Brown; G Galfre; C Milstein; A F Williams; A Ziegler
Journal: Cell Date: 1978-05 Impact factor: 41.582

8. Monoclonal antibody to keratin filaments, specific for glandular epithelia and their tumors. Use in surgical pathology.

Authors: F Ramaekers; A Huysmans; O Moesker; A Kant; P Jap; C Herman; P Vooijs
Journal: Lab Invest Date: 1983-09 Impact factor: 5.662

9. Human colon adenocarcinoma cells. II. Tumorigenic and organoid expression in vivo and in vitro.

Authors: B H Tom; L P Rutzky; R Oyasu; J T Tomita; D M Goldenberg; B D Kahan
Journal: J Natl Cancer Inst Date: 1977-05 Impact factor: 13.506

10. Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

Authors: P P Jones
Journal: J Exp Med Date: 1977-11-01 Impact factor: 14.307

107 in total

1. Cytokeratin expression and early lens development.

Authors: M Kasper; C Viebahn
Journal: Anat Embryol (Berl) Date: 1992-08

2. Monoclonal antibody Cam 5.2 targeted mainly CK8, but not CK18--Comment on: "Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation--report of a unique case. Int J Clin Exp Pathol. 2010 May 5; 3 (5):534-40.".

Authors: Chang Kuang Leei; Wea-Lung Lin; Chih-Ping Han
Journal: Int J Clin Exp Pathol Date: 2010-08-20

3. Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.

Authors: C Doglioni; P Dell'Orto; G Zanetti; P Iuzzolino; G Coggi; G Viale
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1990

Monoclonal antibody to cytokeratin for use in routine histopathology.

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

2. A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.

3. The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique.

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

5. Expression of endodermally derived and neural crest-derived differentiation antigens by human lung and colon tumors.

6. Classification of human colorectal adenocarcinoma cell lines.

7. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.

8. Monoclonal antibody to keratin filaments, specific for glandular epithelia and their tumors. Use in surgical pathology.

9. Human colon adenocarcinoma cells. II. Tumorigenic and organoid expression in vivo and in vitro.

10. Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

1. Cytokeratin expression and early lens development.

2. Monoclonal antibody Cam 5.2 targeted mainly CK8, but not CK18--Comment on: "Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation--report of a unique case. Int J Clin Exp Pathol. 2010 May 5; 3 (5):534-40.".

3. Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.

4. Differential expression of antigens by human small cell lung carcinoma in sections of tumour and in serous effusions.

5. Lactate dehydrogenase (LDH) isoenzymes and proliferative activity of lymphoid cells--an immunocytochemical study.

6. Anticytokeratin CAM 5.2 does not correspond to antibodies CK 8/18.

7. The isolation and description of LIF-10: a human tumor cell line derived from a colorectal adenocarcinoma.

8. Development of human fetal lung in organ culture compared with in utero ontogeny.

9. Patterns of cytokeratin expression by neoplastic and non-neoplastic epithelium.

10. Keratin profiles of normal and malignant oral mucosa using exfoliative cytology.