Literature DB >> 620485

Optimal phenytoin therapy: a new technique for individualizing dosage.

P W Mullen.   

Abstract

A simple, new technique (the direct linear plot) for predicting steady-state serum phenytoin concentrations is described. Although no calculations are required, reliable estimates (comparable with those derived by computer) of the Michaelis-Menten parameters can be readily determined and used graphically to predict the individualized dose required to achieve a desired serum concentration.

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Year:  1978        PMID： 620485     DOI： 10.1002/cpt1978232228

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  22 in total

Review 1.  Therapeutic drug monitoring of phenytoin. Rationale and current status.

Authors:  M Levine; T Chang
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447

2.  Classical Michaelis-Menten and system theory approach to modeling metabolite formation kinetics.

Authors:  Jovan Popović
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Jul-Sep       Impact factor: 2.441

Review 3.  Bayesian parameter estimation and population pharmacokinetics.

Authors:  A H Thomson; B Whiting
Journal:  Clin Pharmacokinet       Date:  1992-06       Impact factor: 6.447

4.  Evaluation of a bayesian pharmacokinetic program for phenytoin concentration predictions in outpatient population.

Authors:  J M Gaulier; R Boulieu; C Fischer
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1998 Apr-Jun       Impact factor: 2.441

5.  Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics.

Authors:  G Lam; W L Chiou
Journal:  J Pharmacokinet Biopharm       Date:  1979-04

6.  Clinical application of the Mullen and Foster method for individualizing phenytoin dosage.

Authors:  T Valenza; A Messori; G Zaccara; G Arnetoli; C Bartoli; G Donati-Cori; G C Muscas; R Silvano; E Tendi; R Zappoli
Journal:  Ital J Neurol Sci       Date:  1984-06

7.  Steady-state pharmacokinetics of phenytoin from routinely collected patient data.

Authors:  T H Grasela; L B Sheiner; B Rambeck; H E Boenigk; A Dunlop; P W Mullen; J Wadsworth; A Richens; T Ishizaki; K Chiba
Journal:  Clin Pharmacokinet       Date:  1983 Jul-Aug       Impact factor: 6.447

8.  Phenytoin dosage predictions in paediatric patients.

Authors:  G J Yuen; P T Latimer; L C Littlefield; R W Mackey
Journal:  Clin Pharmacokinet       Date:  1989-04       Impact factor: 6.447

Review 9.  An updated comparison of drug dosing methods. Part I: Phenytoin.

Authors:  R D Pryka; K A Rodvold; S M Erdman
Journal:  Clin Pharmacokinet       Date:  1991-03       Impact factor: 6.447

10.  Rapid and slow release phenytoin in epileptic patients at steady state: assessment of relative bioavailability utilizing Michaelis-Menten parameters.

Authors:  R J Sawchuk; S M Pepin; I E Leppik; R J Gumnit
Journal:  J Pharmacokinet Biopharm       Date:  1982-08
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