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Literature DB >> 20218016

Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics.

Abstract

Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 20218016 DOI： 10.1007/bf01059740

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

15 in total

1. Elimination of alcohol from human blood.

Authors: J G Wagner; P K Wilkinson; A J Sedman; D R Kay; D J Weidler
Journal: J Pharm Sci Date: 1976-01 Impact factor: 3.534

2. Dose-dependent kinetics of theophylline disposition in asthmatic children.

Authors: M Weinberger; E Ginchansky
Journal: J Pediatr Date: 1977-11 Impact factor: 4.406

3. A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments.

Authors: A Richens
Journal: Epilepsia Date: 1975-11 Impact factor: 5.864

10. Acute intoxication with 5,5-diphenylhydantoin (Dilantin) associated with impairment of biotransformation. Plasma levels and urinary metabolites; and studies in healthy volunteers.

Authors: N Gerber; R Lynn; J Oates
Journal: Ann Intern Med Date: 1972-11 Impact factor: 25.391

3 in total

Review 1. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II).

Authors: W L Chiou
Journal: Clin Pharmacokinet Date: 1989-10 Impact factor: 6.447

Review 2. Stable isotopes in clinical pharmacokinetic investigations. Advantages and disadvantages.

Authors: T R Browne
Journal: Clin Pharmacokinet Date: 1990-06 Impact factor: 6.447

3. Application of modified Michaelis - Menten equations for determination of enzyme inducing and inhibiting drugs.

Authors: Saganuwan Alhaji Saganuwan
Journal: BMC Pharmacol Toxicol Date: 2021-10-11 Impact factor: 2.483

3 in total

Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics.

1. Elimination of alcohol from human blood.

2. Dose-dependent kinetics of theophylline disposition in asthmatic children.

3. A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments.

4. Pharmacokinetic study of a patient with diphenylhydantoin toxicity.

5. Salicylate accumulation kinetics in man.

6. Pharmacokinetics of alcohol following single low doses to fasted and nonfasted subjects.

7. The clinical pharmacokinetics of phenytoin.

8. Phenytoin: pharmacokinetics and bioavailability.

9. Diphenylhydantoin elimination kinetics in overdosed children.

10. Acute intoxication with 5,5-diphenylhydantoin (Dilantin) associated with impairment of biotransformation. Plasma levels and urinary metabolites; and studies in healthy volunteers.

Review 1. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II).

Review 2. Stable isotopes in clinical pharmacokinetic investigations. Advantages and disadvantages.

3. Application of modified Michaelis - Menten equations for determination of enzyme inducing and inhibiting drugs.