Literature DB >> 6203593

Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization.

S M Moochhala, J Sawynok.   

Abstract

The hyperalgesic effect of intrathecally administered substance P (SP), physalaemin, eledoisin and eledoisin-related peptide (ERP) was investigated in the rat tail flick test. Hyperalgesia produced by SP (2.5-15 micrograms, 1.9-11 nmol) was maximal 10-20 min after injection, lasted 30 min and was dose-related. The effect was mimicked by all of the peptides examined. The rank order of potency was physalaemin greater than SP greater than eledoisin greater than ERP. Desensitization to the hyperalgesic effect of SP was produced by three repeated intrathecal injections. Rats desensitized to SP no longer responded to physalaemin or ERP, indicating cross-desensitization. Phentolamine continued to produce hyperalgesia following such desensitization. The demonstration of a hyperalgesic effect for SP provides further support for a role for SP in nociceptive transmission. The receptor mediating this effect appears to be a SP-P subtype. Cross-desensitization between peptides suggests an action on the same receptor.

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Year:  1984        PMID： 6203593      PMCID： PMC1987042          DOI： 10.1111/j.1476-5381.1984.tb10773.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  27 in total

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Journal:  Science       Date:  1978-03-24       Impact factor: 47.728

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Journal:  Br J Pharmacol       Date:  1979-07       Impact factor: 8.739

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Journal:  Nature       Date:  1974-12-20       Impact factor: 49.962

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Journal:  Brain Res       Date:  1974-01-18       Impact factor: 3.252

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  10 in total

1.  Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes.

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Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

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Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

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Journal:  J Pain       Date:  2009-02-23       Impact factor: 5.820

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

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Authors:  Tamara King; Luis R Gardell; Ruizhong Wang; Anna Vardanyan; Michael H Ossipov; Philip T Malan; Todd W Vanderah; Stephen P Hunt; Victor J Hruby; Josephine Lai; Frank Porreca
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Authors:  Luigi A Morrone; Damiana Scuteri; Laura Rombolà; Hirokazu Mizoguchi; Giacinto Bagetta
Journal:  Curr Neuropharmacol       Date:  2017-04       Impact factor: 7.363
  10 in total

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