Literature DB >> 228392

Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.

T L Yaksh, D H Farb, S E Leeman, T M Jessell.   

Abstract

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.

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Year:  1979        PMID： 228392     DOI： 10.1126/science.228392

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

Review 1.  Transient receptor potential channels in pain and inflammation: therapeutic opportunities.

Authors:  Mark A Schumacher
Journal:  Pain Pract       Date:  2010-03-02       Impact factor: 3.183

2.  Neurogenic and tissue-mediated components of formalin-induced edema: evidence for supraspinal regulation.

Authors:  H Wheeler-Aceto; A Cowan
Journal:  Agents Actions       Date:  1991-09

3.  Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.

Authors:  Daniel J Cavanaugh; Hyosang Lee; Liching Lo; Shannon D Shields; Mark J Zylka; Allan I Basbaum; David J Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-18       Impact factor: 11.205

4.  Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.

Authors:  Matthew R Sapio; John K Neubert; Danielle M LaPaglia; Dragan Maric; Jason M Keller; Stephen J Raithel; Eric L Rohrs; Ethan M Anderson; John A Butman; Robert M Caudle; Dorothy C Brown; John D Heiss; Andrew J Mannes; Michael J Iadarola
Journal:  J Clin Invest       Date:  2018-03-19       Impact factor: 14.808

5.  Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.

Authors:  Michael A Eskander; Shivani Ruparel; Dustin P Green; Paul B Chen; Elaine D Por; Nathaniel A Jeske; Xiaoli Gao; Eric R Flores; Kenneth M Hargreaves
Journal:  J Neurosci       Date:  2015-06-03       Impact factor: 6.167

6.  Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.

Authors:  Y De Koninck; J L Henry
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

7.  Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats.

Authors:  Joshua Havelin; Ian Imbert; Devki Sukhtankar; Bethany Remeniuk; Ian Pelletier; Jonathan Gentry; Alec Okun; Timothy Tiutan; Frank Porreca; Tamara E King
Journal:  J Neurosci       Date:  2017-04-24       Impact factor: 6.167

8.  Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.

Authors:  Juan Carlos Marvizon; Wenling Chen; Weisi Fu; Bradley K Taylor
Journal:  Neuropharmacology       Date:  2019-08-02       Impact factor: 5.250

9.  TRPV1: a target for next generation analgesics.

Authors:  Louis S Premkumar; Parul Sikand
Journal:  Curr Neuropharmacol       Date:  2008-06       Impact factor: 7.363

10.  Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.

Authors:  Joseph A Jeffry; Shuang-Quan Yu; Parul Sikand; Arti Parihar; M Steven Evans; Louis S Premkumar
Journal:  PLoS One       Date:  2009-09-15       Impact factor: 3.240
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