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Literature DB >> 6201756

Regional studies of myelin proteins in human brain and spinal cord.

J L Trotter, C L Wegescheide, W F Garvey.

Abstract

The myelin specific proteins, myelin basic protein (MBP) and myelin proteolipid protein (PLP) were quantitated by radioimmunoassay (RIA) and the activity of the enzyme 2',3'-cyclic 3' phosphohydrolase (CNP) measured, in 27 regions of normal brain and spinal cord. Varying regional concentrations for each protein and regional variations for protein ratios were noted, supporting the concept of a varying chemical composition for myelin throughout the central nervous system (CNS). Variation was also noted among myelin subfractions from a single region. Regions with special sensitivity to the multiple sclerosis process had relatively lower proportions of CNP in several, but not all cases.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6201756 DOI： 10.1007/bf00967665

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

34 in total

1. The relation of proteolipids and phosphatidopeptides to tissue elements in the bovine nervous system.

Authors: L AMADUCCI; A PAZZAGLI; G PESSINA
Journal: J Neurochem Date: 1962 Sep-Oct Impact factor: 5.372

2. The isolation from bovine spinal cord of a homogeneous protein with encephalitogenic activity.

Authors: E R EINSTEIN; D M ROBERTSON; J M DICAPRIO; W MOORE
Journal: J Neurochem Date: 1962 Jul-Aug Impact factor: 5.372

3. Morphological and biochemical characterization of light and heavy myelin isolated from developing rat brain.

Authors: K Fujimoto; B I Roots; R M Burton; H C Agrawal
Journal: Biochim Biophys Acta Date: 1976-04-05

4. Isolation and some chemical properties of oligodendroglia from calf brain.

Authors: S E Poduslo; W T Norton
Journal: J Neurochem Date: 1972-03 Impact factor: 5.372

5. Studies of the catabolism of myelin basic proteins of the rat in situ and in vitro.

Authors: R Sammeck; R O Brady
Journal: Brain Res Date: 1972-07-20 Impact factor: 3.252

6. Purification and immunohistochemical localization of rat brain myelin proteolipid protein.

Authors: H C Agrawal; B K Hartman; W T Shearer; S Kalmbach; F L Margolis
Journal: J Neurochem Date: 1977-03 Impact factor: 5.372

7. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.

Authors: G E Deibler; R E Martenson; M W Kies
Journal: Prep Biochem Date: 1972

8. A comparative study of the immunohistochemical localization of basic protein to myelin and oligodendrocytes in rat and chicken brain.

Authors: B K Hartman; H C Agrawal; S Kalmbach; W T Shearer
Journal: J Comp Neurol Date: 1979-11-15 Impact factor: 3.215

Regional studies of myelin proteins in human brain and spinal cord.

1. The relation of proteolipids and phosphatidopeptides to tissue elements in the bovine nervous system.

2. The isolation from bovine spinal cord of a homogeneous protein with encephalitogenic activity.

3. Morphological and biochemical characterization of light and heavy myelin isolated from developing rat brain.

4. Isolation and some chemical properties of oligodendroglia from calf brain.

5. Studies of the catabolism of myelin basic proteins of the rat in situ and in vitro.

6. Purification and immunohistochemical localization of rat brain myelin proteolipid protein.

7. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.

8. A comparative study of the immunohistochemical localization of basic protein to myelin and oligodendrocytes in rat and chicken brain.

9. Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.

10. Immunocytochemical localization studies of myelin basic protein.

1. Spinal cord transcriptome analysis using suppression subtractive hybridization and mirror orientation selection.

2. Murine spinal cord transcriptome analysis following reduction of prevalent myelin cDNA sequences.

3. Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.

4. Studies of myelin proteins in multiple sclerosis brain tissue.

5. Feasibility of imaging myelin lesions in multiple sclerosis.