Literature DB >> 6201757

Studies of myelin proteins in multiple sclerosis brain tissue.

J L Trotter, C L Wegescheide, W F Garvey, W W Tourtellotte.   

Abstract

Using radioimmunoassays (RIA) for the myelin specific proteins, myelin proteolipid protein (PLP) and myelin basic protein (MBP) and an enzyme assay for the activity of the myelin marker enzyme 2'3' cyclic-3' phosphohydrolase (CNPase), we have studied plaque, periplaque and normal appearing white matter (NAWM) tissue. We found that all three mylein proteins are decreased in all regions, including NAWM, of MS brain, with a decreasing gradient from NAWM to perregion. Surprisingly, when the ratios of the proteins were calculated, MBP activity, although decreased was found to be relatively preserved.

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Year:  1984        PMID： 6201757     DOI： 10.1007/bf00967666

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  18 in total

1.  Myelin in multiple sclerosis. Composition of myelin from normal-appearing white matter.

Authors:  K Suzuki; S Kamoshita; Y Eto; W W Tourtellotte; J O Gonatas
Journal:  Arch Neurol       Date:  1973-05

2.  Protein composition of multiple sclerosis myelin.

Authors:  P J Riekkinen; J Palo; A U Arstila; H J Savolainen; U K Rinne; E K Kivalo; H Frey
Journal:  Arch Neurol       Date:  1971-06

3.  Increased protease activity and changes in basic proteins and lipids in multiple sclerosis plaques.

Authors:  E R Einstein; K B Dalal; J Csejtey
Journal:  J Neurol Sci       Date:  1970-08       Impact factor: 3.181

4.  Purification and immunohistochemical localization of rat brain myelin proteolipid protein.

Authors:  H C Agrawal; B K Hartman; W T Shearer; S Kalmbach; F L Margolis
Journal:  J Neurochem       Date:  1977-03       Impact factor: 5.372

5.  Lipid and protein alterations of spinal cord and cord myelin of multiple sclerosis.

Authors:  R K Yu; K Ueno; G H Glaser; W W Tourtellotte
Journal:  J Neurochem       Date:  1982-08       Impact factor: 5.372

6.  2',3'-Cyclic nucleotide 3'-phosphohydrolase and lipids of myelin from multiple sclerosis and normal brains.

Authors:  E Göpfert; S Pytlik; H Debuch
Journal:  J Neurochem       Date:  1980-03       Impact factor: 5.372

7.  White matter proteins in multiple sclerosis.

Authors:  J Newcombe; M L Cuzner; M Röyttä; H Frey
Journal:  J Neurochem       Date:  1980-03       Impact factor: 5.372

8.  Radioimmunoassay for central nervous system myelin-specific proteolipid protein.

Authors:  J L Trotter; L Lieberman; F L Margolis; H C Agrawal
Journal:  J Neurochem       Date:  1981-03       Impact factor: 5.372

9.  Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions.

Authors:  Y Itoyama; N H Sternberger; H D Webster; R H Quarles; S R Cohen; E P Richardson
Journal:  Ann Neurol       Date:  1980-02       Impact factor: 10.422

10.  The distribution of myelin basic protein in central nervous system lesions of multiple sclerosis and acute experimental allergic encephalomyelitis.

Authors:  J N Whitaker
Journal:  Ann Neurol       Date:  1978-04       Impact factor: 10.422
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  4 in total

1.  Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis.

Authors:  Oscar A Bizzozero; Gisela DeJesus; Heather A Bixler; Andrzej Pastuszyn
Journal:  Neurochem Res       Date:  2005-01       Impact factor: 3.996

2.  Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis.

Authors:  A M Saindane; M Law; Y Ge; G Johnson; J S Babb; R I Grossman
Journal:  AJNR Am J Neuroradiol       Date:  2007-04       Impact factor: 3.825

3.  Feasibility of imaging myelin lesions in multiple sclerosis.

Authors:  Maria I Zavodszky; John F Graf; Cristina A Tan Hehir
Journal:  Int J Biomed Imaging       Date:  2011-08-15

4.  A Unique TGFB1-Driven Genomic Program Links Astrocytosis, Low-Grade Inflammation and Partial Demyelination in Spinal Cord Periplaques from Progressive Multiple Sclerosis Patients.

Authors:  Serge Nataf; Marc Barritault; Laurent Pays
Journal:  Int J Mol Sci       Date:  2017-10-05       Impact factor: 5.923
  4 in total

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