Literature DB >> 6200932

Plasmodium knowlesi sporozoite antigen: expression by infectious recombinant vaccinia virus.

G L Smith, G N Godson, V Nussenzweig, R S Nussenzweig, J Barnwell, B Moss.   

Abstract

The gene coding for the circumsporozoite antigen of the malaria parasite Plasmodium knowlesi was inserted into the vaccinia virus genome under the control of a defined vaccinia virus promoter. Cells infected with the recombinant virus synthesized polypeptides of 53,000 to 56,000 daltons that reacted with monoclonal antibody against the repeating epitope of the malaria protein. Furthermore, rabbits vaccinated with the recombinant virus produced antibodies that bound specifically to sporozoites. These data provide evidence for expression of a cloned malaria gene in mammalian cells and illustrate the potential of vaccinia virus recombinants as live malaria vaccines.

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Year:  1984        PMID： 6200932     DOI： 10.1126/science.6200932

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  The immunogenicity of VP7, a rotavirus antigen resident in the endoplasmic reticulum, is enhanced by cell surface expression.

Authors:  M E Andrew; D B Boyle; P L Whitfeld; L J Lockett; I D Anthony; A R Bellamy; G W Both
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

Review 2.  Use of vaccinia virus to express biopharmaceutical products.

Authors:  D E Hruby; G Thomas
Journal:  Pharm Res       Date:  1987-04       Impact factor: 4.200

Review 3.  Plasmodium falciparum antigens as target molecules for a protective immunization against malaria: an up-to-date review.

Authors:  H G Heidrich
Journal:  Z Parasitenkd       Date:  1986

Review 4.  Human poxvirus infection after the eradication of smallpox.

Authors:  D Baxby
Journal:  Epidemiol Infect       Date:  1988-06       Impact factor: 2.451

5.  Synthesis, cellular location, and immunogenicity of bovine herpesvirus 1 glycoproteins gI and gIII expressed by recombinant vaccinia virus.

Authors:  S van Drunen Littel-van den Hurk; T Zamb; L A Babiuk
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

6.  Anchoring a secreted plasmodium antigen on the surface of recombinant vaccinia virus-infected cells increases its immunogenicity.

Authors:  C J Langford; S J Edwards; G L Smith; G F Mitchell; B Moss; D J Kemp; R F Anders
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

7.  Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.

Authors:  E J Hogervorst; L Schouls; J P Wagenaar; C J Boog; W J Spaan; J D van Embden; W van Eden
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

8.  Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus.

Authors:  J A Tine; V Conseil; P Delplace; C De Taisne; D Camus; E Paoletti
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

9.  Vaccinia virus recombinants expressing an 11-kilodalton beta-galactosidase fusion protein incorporate active beta-galactosidase in virus particles.

Authors:  C Huang; W A Samsonoff; A Grzelecki
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

10.  One hundred base pairs of 5' flanking sequence of a vaccinia virus late gene are sufficient to temporally regulate late transcription.

Authors:  C Bertholet; R Drillien; R Wittek
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205
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