Literature DB >> 6200563

An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants.

D H Sherr, M E Dorf.   

Abstract

A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surface phenotype is Lyt-1.2+, Ig+, Lyb-3+, Thy-1.2-, Lyt-2.2-. The helper activity of the BH population is IgH restricted and BH cells selectively bind NPb idiotypic determinants. Collectively the data demonstrate that this unique subpopulation can regulate the response of antibody-secreting B cells through specific recognition of idiotypic determinants.

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Year:  1984        PMID： 6200563      PMCID： PMC2187269          DOI： 10.1084/jem.159.4.1189

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  24 in total

1.  The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

Authors:  N A Mitchison
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

2.  Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody.

Authors:  R Woodland; H Cantor
Journal:  Eur J Immunol       Date:  1978-08       Impact factor: 5.532

3.  A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors:  M H Julius; E Simpson; L A Herzenberg
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

4.  Molecular identification of a surface structure on B cells (Lyb-3) and its relationship to B cell triggering.

Authors:  R E Cone; B Huber; H Cantor; R K Gershon
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

5.  Towards a network theory of the immune system.

Authors:  N K Jerne
Journal:  Ann Immunol (Paris)       Date:  1974-01

6.  Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells.

Authors:  J Z Weinberger; R N Germain; S T Ju; M I Greene; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1979-10-01       Impact factor: 14.307

7.  Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.

Authors:  K Bottomly; B J Mathieson; D E Mosier
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

8.  Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

Authors:  T Tada; T Takemori; K Okumura; M Nonaka; T Tokuhisa
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307

9.  Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

Authors:  B Huber; R K Gershon; H Cantor
Journal:  J Exp Med       Date:  1977-01-01       Impact factor: 14.307

10.  Purification of functional, determinant-specific, idiotype-bearing murine T cells.

Authors:  G K Lewis; J W Goodman
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307
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  10 in total

1.  The role of antibodies in the regulation of delayed-type hypersensitivity.

Authors:  Y Morikawa; K Kuribayashi; F Yoshikawa; K Fujita; A Mizushima; K Kakudo
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

2.  B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes.

Authors:  J H Antin; K A Ault; J M Rappeport; B R Smith
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

3.  CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies.

Authors:  T J Kipps; B A Robbins; A Tefferi; G Meisenholder; P M Banks; D A Carson
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

4.  Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens.

Authors:  J R Hiernaux; P J Baker; S J McEvoy; P W Stashak; M B Fauntleroy; E A Goidl
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

5.  The Leu-1 B-cell subpopulation in patients with rheumatoid arthritis.

Authors:  O Taniguchi; H Miyajima; T Hirano; M Noguchi; A Ueda; H Hashimoto; S Hirose; K Okumura
Journal:  J Clin Immunol       Date:  1987-11       Impact factor: 8.317

6.  Down-regulation of suppressor cell induction.

Authors:  V K Kuchroo; T Noma; M Minami; M E Dorf
Journal:  Immunology       Date:  1988-08       Impact factor: 7.397

7.  Immunopathology of non-Hodgkin lymphomas.

Authors:  H Huber; C Gattringer; W Knapp; H Stein
Journal:  Klin Wochenschr       Date:  1984-11-02

8.  Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes.

Authors:  J G Karras; Z Wang; L Huo; R G Howard; D A Frank; T L Rothstein
Journal:  J Exp Med       Date:  1997-03-17       Impact factor: 14.307

9.  Unusual phenotype of B cells in the thymus of normal mice.

Authors:  M Miyama-Inaba; S Kuma; K Inaba; H Ogata; H Iwai; R Yasumizu; S Muramatsu; R M Steinman; S Ikehara
Journal:  J Exp Med       Date:  1988-08-01       Impact factor: 14.307

10.  Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

Authors:  T J Kipps; E Tomhave; P P Chen; D A Carson
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307
  10 in total

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