Literature DB >> 309912

Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.

K Bottomly, B J Mathieson, D E Mosier.   

Abstract

An adoptive secondary antibody response to phosphorylcholine (PC) can be generated by the transfer of keyhole limpet hemocyanin (KLH)-primed T cells, PC-bovine gamma globulin-primed B cells, and PC-KLH into irradiated syngeneic BALB/c mice. If the KLH-primed T-cell donors were pretreated with anti-idiotype antibodies directed against the BALB/c PC-binding myeloma TEPC 15, their T cells were unable to collaborate effectively with PC-primed B cells; moreover, they could suppress the helper activity of T cells from normal mice for the PC-KLH response. The Ly phenotype of these T cells was found to be Ly 1-, 2+. The specificity of the suppressor T-cell population induced by anti-T15 treatment appears to be both for idiotype (hapten) and carrier, since the suppressor T cells fail to interfere with the antibody response to PC on a heterologous carrier, nor do they suppress the response to trinitrophenol-KLH.

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Year:  1978        PMID： 309912      PMCID： PMC2185045          DOI： 10.1084/jem.148.5.1216

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  21 in total

1.  Plaque formation in agar by single antibody-producing cells.

Authors:  N K JERNE; A A NORDIN
Journal:  Science       Date:  1963-04-26       Impact factor: 47.728

2.  Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.

Authors:  H Y Tse; R W Dutton
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307

Review 3.  Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.

Authors:  H Cosenza; M H Julius; A A Augustin
Journal:  Immunol Rev       Date:  1977       Impact factor: 12.988

4.  Neonatal tolerance induced by antibody against antigen-specific receptor.

Authors:  D S Strayer; H Cosenza; W M Lee; D A Rowley; H Köhler
Journal:  Science       Date:  1974-11-15       Impact factor: 47.728

5.  Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine.

Authors:  A Sher; M Cohn
Journal:  Eur J Immunol       Date:  1972-08       Impact factor: 5.532

6.  Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.

Authors:  M B Rittenberg; K L Pratt
Journal:  Proc Soc Exp Biol Med       Date:  1969-11

7.  Idiotype suppression. II. Amplification of a suppressor T cell with anti-idiotypic activity.

Authors:  K Eichmann
Journal:  Eur J Immunol       Date:  1975-08       Impact factor: 5.532

8.  Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody.

Authors:  H Cosenza; H Köhler
Journal:  Science       Date:  1972-06-02       Impact factor: 47.728

9.  Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells.

Authors:  P J Baker; P W Stashak; B Prescott
Journal:  Appl Microbiol       Date:  1969-03

10.  Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine.

Authors:  R Lieberman; M Potter; E B Mushinski; W Humphrey; S Rudikoff
Journal:  J Exp Med       Date:  1974-04-01       Impact factor: 14.307
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  34 in total

Review 1.  Autoregulation of immune responses via idiotype network interactions.

Authors:  L S Rodkey
Journal:  Microbiol Rev       Date:  1980-12

2.  Immunoregulatory effects of covalent antigen-antibody complexes. IV. Priming and tolerance in T-dependent responses.

Authors:  J P Tite; C A Morrison; R B Taylor
Journal:  Immunology       Date:  1982-08       Impact factor: 7.397

Review 3.  Developmental aspects of B-cell repertoire phenotype.

Authors:  M P Cancro; M A Thompson; D M Hilbert
Journal:  Surv Immunol Res       Date:  1983

Review 4.  Repositioning TH cell polarization from single cytokines to complex help.

Authors:  Selma Tuzlak; Florent Ginhoux; Thomas Korn; Burkhard Becher; Anne S Dejean; Matteo Iannacone; Francisco J Quintana; Ari Waisman
Journal:  Nat Immunol       Date:  2021-09-20       Impact factor: 25.606

5.  The assessment of anti-idiopathic antibodies as effective immunoregulatory probes in vivo.

Authors:  J C Olson; C R Wagner; G A Leslie
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

6.  Microheterogeneity in regulatory circuits for T-cell alloresponsiveness.

Authors:  R M Gorczynski; S Macrae
Journal:  Immunology       Date:  1981-12       Impact factor: 7.397

7.  Preparation and characterization of the anti-idiotypic properties of rabbit anti-timothy antigen B helper factor and anti-mouse timothy IgE antisera.

Authors:  A Malley; C J Brandt; L B Deppe
Journal:  Immunology       Date:  1982-02       Impact factor: 7.397

8.  Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells.

Authors:  K Bottomly; B Jones; J Kaye; F Jones
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

9.  Induction of idiotype-bearing, nuclease-specific helper T cells by in vivo treatment with anti-idiotype.

Authors:  G G Miller; P I Nadler; Y Asano; R J Hodes; D H Sachs
Journal:  J Exp Med       Date:  1981-07-01       Impact factor: 14.307

10.  Antiidiotypes against anti-H-2 monoclonal antibodies. V. In vivo antiidiotype treatment induces idiotype-specific helper T cells.

Authors:  H Auchincloss; J A Bluestone; D H Sachs
Journal:  J Exp Med       Date:  1983-04-01       Impact factor: 14.307
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