| Literature DB >> 6200116 |
C J Meade, J Harvey, J R Boot, G A Turner, P E Bateman, D J Osborne.
Abstract
gamma-Hexachlorocyclohexane stimulates arachidonic acid release from macrophage phospholipids. It is also a powerful stimulator of leukotriene C4 production, yet (by comparison with zymosan) produces only a small effect on prostaglandin production. This suggests that synthesis of leukotrienes and prostaglandins can be independently regulated. The most likely mechanism of action of gamma-hexachlorocyclohexane is through its effect on phosphatidylinositol metabolism.Entities:
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Year: 1984 PMID： 6200116 DOI： 10.1016/0006-2952(84)90487-8
Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858