Literature DB >> 9021763

Non-muscarinic- and non-adrenergic-mediated effects of lindane on phosphoinositide hydrolysis in rat brain cortex slices.

L Pajuelo1, J A Sánchez-Alonso, N del Hoyo, J A Pulido, M A Pérez-Albarsanz.   

Abstract

The influence of lindane upon phosphatidylinositol hydrolysis in rat brain cortex slices has been investigated using anion-exchange chromatography in order to separate the water-soluble inositol metabolites. Acetylcholine, noradrenaline, and lindane induce the accumulation of myo-[2-3H]inositol as the water-soluble inositol metabolites. However, the cholinergic muscarinic antagonist atropine inhibited the stimulatory response of carbachol, but practically unmodified the effect that lindane has on inositol phosphate production. Also, prazosin anti-alpha 1 adrenoreceptors blocked noradrenaline-induced phosphoinositide hydrolysis, but had no effect on lindane-induced increase of inositol phosphate levels. The results suggest that lindane does not exert a general effect on the receptor-stimulated formation of inositol phosphates by both muscarinic and alpha 1-adrenergic agonists.

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Year:  1997        PMID： 9021763     DOI： 10.1023/a:1027377321041

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  40 in total

1.  Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization.

Authors:  R A Challiss; I H Batty; S R Nahorski
Journal:  Biochem Biophys Res Commun       Date:  1988-12-15       Impact factor: 3.575

2.  The effects of gamma-hexachlorocyclohexane on amylase secretion and inositol phospholipid metabolism in mouse pancreatic acini.

Authors:  M F Crouch; M L Roberts
Journal:  Biochim Biophys Acta       Date:  1985-02-21

3.  Relationship between lindane concentration in blood and brain and convulsant response in rats after oral or intraperitoneal administration.

Authors:  J M Tusell; C Suñol; E Gelpí; E Rodríguez-Farré
Journal:  Arch Toxicol       Date:  1987-08       Impact factor: 5.153

Review 4.  Mode of action of lindane, dieldrin and related insecticides in the central nervous system.

Authors:  R M Joy
Journal:  Neurobehav Toxicol Teratol       Date:  1982 Nov-Dec

5.  The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction.

Authors:  S J Publicover; C J Duncan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

6.  Stimulation of DNA synthesis any myo-inositol incorporation in mammalian cells.

Authors:  H J Ristow; T O Messmer; S Walter; D Paul
Journal:  J Cell Physiol       Date:  1980-05       Impact factor: 6.384

7.  Differential effects of alkylating agents on the multiple muscarinic receptor subtypes linked to activation of phospholipase C by carbachol in rat brain cortical membranes.

Authors:  J Sallés; M A Wallace; J N Fain
Journal:  J Pharmacol Exp Ther       Date:  1993-02       Impact factor: 4.030

8.  The effects of different hexachlorocyclohexanes and cyclodienes on glucose uptake and inositol phospholipid synthesis in rat brain cortex.

Authors:  J A Pulido; N del Hoyo; M A Pérez-Albarsanz
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

9.  Effect of lindane on phosphatidylinositol synthesis by cerebral cortex after acute and subchronic treatment.

Authors:  N del Hoyo; J A Pulido; M A Pérez-Albarsanz
Journal:  Int J Biochem       Date:  1993-12

10.  gamma-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization of O2- production.

Authors:  A Holian; M A Marchiarullo; D F Stickle
Journal:  FEBS Lett       Date:  1984-10-15       Impact factor: 4.124
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