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Literature DB >> 6199844

Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor.

Y Shing, J Folkman, R Sullivan, C Butterfield, J Murray, M Klagsbrun.

Abstract

A tumor-derived growth factor that stimulates the proliferation of capillary endothelial cells has a very strong affinity for heparin. This heparin affinity makes it possible to purify the growth factor to a single-band preparation in a rapid two-step procedure. The purified growth factor is a cationic polypeptide, has a molecular weight of about 18,000, and stimulates capillary endothelial cell proliferation at a concentration of about 1 nanogram per milliliter.

Entities: Chemical Disease

Mesh：

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Year: 1984 PMID： 6199844 DOI： 10.1126/science.6199844

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

172 in total

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Authors: J C Davis; G Venkataraman; Z Shriver; P A Raj; R Sasisekharan
Journal: Biochem J Date: 1999-08-01 Impact factor: 3.857

2. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.

Authors: Atsushi Otani; Bonnie M Slike; Michael I Dorrell; John Hood; Karen Kinder; Karla L Ewalt; David Cheresh; Paul Schimmel; Martin Friedlander
Journal: Proc Natl Acad Sci U S A Date: 2002-01-02 Impact factor: 11.205

Review 3. Vascular potential of human pluripotent stem cells.

Authors: Ionela Iacobas; Archana Vats; Karen K Hirschi
Journal: Arterioscler Thromb Vasc Biol Date: 2010-05-07 Impact factor: 8.311

4. The role of the vascular phase in solid tumor growth: a historical review.

Authors: D Ribatti; A Vacca; F Dammacco
Journal: Neoplasia Date: 1999-10 Impact factor: 5.715

5. Partial purification of smooth muscle cell derived growth factor.

Authors: S Yang; Z Deng; Z Qu
Journal: J Tongji Med Univ Date: 1996

6. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

Authors: Robin N Prince; Eric R Schreiter; Peng Zou; H Steven Wiley; Alice Y Ting; Richard T Lee; Douglas A Lauffenburger
Journal: J Cell Sci Date: 2010-06-08 Impact factor: 5.285

Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor.

1. Oligomeric self-association of basic fibroblast growth factor in the absence of heparin-like glycosaminoglycans.

2. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.

Review 3. Vascular potential of human pluripotent stem cells.

4. The role of the vascular phase in solid tumor growth: a historical review.

5. Partial purification of smooth muscle cell derived growth factor.

6. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

7. Partial purification and characterization of a growth factor from human hyperplastic prostatic tissues.

Review 8. Angiogenesis and angiogenesis inhibitors in paediatric diseases.

9. Heparin-binding growth factors and their receptors.

Review 10. Angiogenic therapy for cardiac repair based on protein delivery systems.