Literature DB >> 6197360

The role of rabbit Ia molecules in immune functions as determined with the use of an anti-Ia monoclonal antibody.

S A Lobel, K L Knight.   

Abstract

We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibits the mixed lymphocyte culture by 80%. In secondary in vitro immune response cultures, the anti-Ia MAb inhibits the proliferative response to bovine insulin and poly (Glu50Tyr50). In studies on mitogenesis it was found that the anti-Ia MAb inhibited the response to LPS but not to concanavalin A or phytohaemagglutinin. The effect of the anti-Ia MAb on other mitogens was found to vary from rabbit to rabbit.

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Year:  1984        PMID： 6197360      PMCID： PMC1454398     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  17 in total

1.  Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion.

Authors:  R H Schwartz; C S David; M E Dorf; B Benacerraf; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

2.  Histocompatibility in the rabbit. Identification of the major locus.

Authors:  R G Tissot; C Cohen
Journal:  Tissue Antigens       Date:  1972

3.  A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

Authors:  W M Bonner; R A Laskey
Journal:  Eur J Biochem       Date:  1974-07-01

4.  Conjugation of antibodies with fluorochromes: modifications to the standard methods.

Authors:  J W Goding
Journal:  J Immunol Methods       Date:  1976       Impact factor: 2.303

Review 5.  A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

Authors:  B Benacerraf
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

6.  The effect of alloantisera on antigen-induced T cell proliferation.

Authors:  H Ruhl; E M Shevach
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

7.  Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): subregion-specific inhibition of the responses with monoclonal Ia antibodies.

Authors:  C N Baxevanis; D Wernet; Z A Nagy; P H Maurer; J Klein
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

8.  Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia.

Authors:  C Bona; C Damais; L Chedid
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

9.  Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera.

Authors:  E M Shevach; W E Paul; I Green
Journal:  J Exp Med       Date:  1972-11-01       Impact factor: 14.307

10.  The guinea pig I region. II. Functional analysis.

Authors:  E M Shevach; M L Lundquist; A F Geczy; B D Schwartz
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307
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  11 in total

1.  A cytotoxic rabbit T-cell line infected with a gamma-herpes virus which expresses CD8 and class II antigens.

Authors:  J M Wilkinson; J Galea-Lauri; H W Reid
Journal:  Immunology       Date:  1992-09       Impact factor: 7.397

2.  Analysis of T cells and major histocompatibility complex class I and class II mRNA and protein content and distribution in antiglomerular basement membrane disease in the rabbit.

Authors:  C Eldredge; S Merritt; M Goyal; H Kulaga; T J Kindt; R Wiggins
Journal:  Am J Pathol       Date:  1991-11       Impact factor: 4.307

3.  Immunocytochemical and ultrastructural characterization of human T-lymphotropic virus type I (HTLV-I)-producing rabbit lymphoid cell lines.

Authors:  Y Ohtsuki; I Miyoshi; T Oka; K Hayashi; K Takahashi; M Furihata; J Iwata; T Takeuchi; H Sonobe
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

4.  Congenital syphilis in newborn rabbits: immune functions and susceptibility to challenge infection at 2 and 5 weeks of age.

Authors:  T J Fitzgerald; M K Froberg
Journal:  Infect Immun       Date:  1991-05       Impact factor: 3.441

5.  Tissue factor initiates glomerular fibrin deposition and promotes major histocompatibility complex class II expression in crescentic glomerulonephritis.

Authors:  J H Erlich; S R Holdsworth; P G Tipping
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

6.  The relationship between HTLV-I-infected cell lines and uveitis.

Authors:  A Fukushima; H Ueno
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-04       Impact factor: 3.117

7.  Molecular evidence for five distinct MHC class II alpha genes in the rabbit.

Authors:  C LeGuern; P N Marche; T J Kindt
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

8.  Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma.

Authors:  H Li; M I Cybulsky; M A Gimbrone; P Libby
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

9.  Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with the immunoglobulin heavy chain enhancer.

Authors:  K L Knight; H Spieker-Polet; D S Kazdin; V T Oi
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

10.  Selection of rabbit CD4- CD8- T cell receptor-gamma/delta cells by in vitro transformation with human T lymphotropic virus-I.

Authors:  S Sawasdikosol; B F Hague; T M Zhao; F S Bowers; R M Simpson; M Robinson; T J Kindt
Journal:  J Exp Med       Date:  1993-10-01       Impact factor: 14.307
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